Posts tagged with "Oxford"

Hiccup in COVID-19 Vaccine Development

By Althea Champion

In a statement from AstraZeneca, reported by STAT News, the biopharmaceutical company reported a halt in their global research trial. The company, which is working with the University of Oxford and is one of the few waist-deep in the process of developing a COVID-19 vaccination, reported that the halt is a “routine action which has to happen whenever there is a potentially unexplained illness in one of the trials.”

The company is in Phase 3 of their clinical trial in the U.S., as well as Brazil and South Africa, according to the New York Times, and in Phase 2/3 in England and India. AstraZeneca began the third phase of its clinical trial not much longer than a week ago, on Aug. 31.

Phase 3 efficacy trials involve thousands of volunteers, some of which are administered the vaccine in question, and others the placebo.

AstraZeneca and its most close competitors, Moderna and Pfizer, which have each been in phase 3 of their clinical trials since July 27, are backed by the Trump administration’s Operation Warp Speed, a targeted allocation of resources meant to hasten the development of a COVID-19 vaccine. 

The halt of AstraZeneca’s COVID-19 vaccine—AZD1222—is the first made public by its drug maker, and will allow a safety review to take place. 

“A volunteer in the U.K. trial [of AZD1222] had been found to have transverse myelitis, an inflammatory syndrome that affects the spinal cord and is often sparked by viral infections,” reported the New York Times. “However, the timing of this diagnosis, and whether it was directly linked to AstraZeneca’s vaccine, is unclear.”

The vaccine was first developed by Oxford University’s Jenner Institute and Oxford Vaccine Group, according to nih.gov, and was then “licensed to AstraZeneca for further development.” Oxford-Astrazeneca began the third phase of its clinical trial not much longer than a week ago, on Aug. 31

The company stressed in its statement that the safety of their participants is a priority.

“We are working to expedite the review of the single event to minimize any potential impact on the trial timeline,” said the company in their statement. “We are committed to the safety of our participants and the highest standards of conduct in our trials.”

Covid and health illustration

Oxford Vaccine Shows Promising Signs

By Eamonn Burke

A vaccine developed by The University of Oxford in the UK and major pharmaceutical company AstraZeneca has shown early signs of being a potential success. According to data posted today in The Lancet medical journal, a strong immune response was invoked by early testing of the vaccine in a large human trial of over 1,000 participants.

The vaccine, named ChAdOx1 nCoV-19, produced higher levels of antibodies and T-cells that fight the virus, according to the data. In other words, “We’re stimulating both arms of the immune system,” says Oxford’s head of the Jenner Institute Adrian Hill.

By no means does this data guarantee an effective vaccine, but human testing is a major step in the right direction, especially one with positive results. Another good sign is the lack of serious side effects, with most volunteers only reporting fatigue, headache, and soreness at the injection site. Big questions that remain, however, are how the body will react once infected, and if someone can get infected again.

AstraZenaca has received support from the U.S., pledging $1.2 billion dollars to vaccine work, and from the U.K., who has made a deal for 90 million doses of it. It is one of over 100 being developed globally, with 23 in the human trial phase. One of them is Moderna’s, which also showed promising signs in data last week and is set to start a Phase 3 of development on July 27.

Glass Animals, Dave Bayley, Vaughn Lowery, 360 Magazine, Abigail Baldwin, Instagram Live,

Glass Animals – Quarantine Covers

DAVE BAYLEY OF GLASS ANIMALS COVERS “HEART-SHAPED BOX” BY NIRVANA ON INSTAGRAM

WATCH HERE

Glass Animals are bringing fans ‘Quarantine Covers’ Episodes where they’re covering fan-requested songs and going through the gear used to record. While locked in his studio under quarantine, lead singer Dave Bayley of Glass Animals covered Nirvana’s “Heart-Shaped Box” for Episode 1. Watch HERE (http://www.youtube.com/watch?v=8fL2NDcGym4) .

Glass Animals’ brand new single “Your Love (Déjà vu)” is out now and is a tantalizing first hint of what is to come from Glass Animals’ upcoming third studio album. Listen HERE

2020 already promises to be a momentous year for Glass Animals—the universally-adored British four-piece fronted by Dave Bayley with his bandmates and childhood friends, Joe Seaward, Ed Irwin-Singer and Drew Macfarlane. As well as producing both ZABA and How To Be A Human Being, Dave has produced “Your Love (Déjà vu)” and in the past worked with a number of artists outside of the band, including 6lack, Khalid, Joey Bada$$, DJ Dahi, Flume and MorMor. The tone for Glass Animals was set when they dropped bombshell release “Tokyo Drifting” feat. Denzel Curry at the close of last year and celebrated by playing a packed-out, surprise secret show in a tiny venue in Oxford.

It was an important moment for Glass Animals, their first headline show playing together since drummer Joe Seaward’s cycling accident in 2018. The success and reaction to the show fortified the band to announce an extensive but incredibly intimate run of shows around the world this spring—playing some of the spaces they played when they first started out, reminding themselves of what they have and what they nearly lost, and crucially, a big thank you to the fans who supported them throughout.

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Dealing with the Russians

Andrew Monaghan Presents his plan for moving forward with Russia in “Dealing with the Russians”

How to handle Russia? This question has become ever more prominent as the Euro-Atlantic community’s relations with Russia languish in deep in systemic crisis, with dialogue suspended, reciprocal sanctions in place and proxy wars raging. The wars in Ukraine and Syria, accusations of Russian interference in domestic politics and the attempted assassination of the Skripals on UK soil have all contributed to soaring tension in the relationship.

Yet faced with this array of serious challenges, Euro-Atlantic thinking about Russia remains stuck in twentieth-century rhetoric, trapped by misleading abstract labels and unsure whether to engage Moscow in dialogue or enhance deterrence and collective defence. Instead of thinking in these terms, leading Russia expert Andrew Monaghan argues that we must devise a new grand strategy for dealing with the Russians. Examining the ongoing Euro-Atlantic debate over Russia and framing Moscow’s own position towards the West, he sets out the foundations of a forward-looking strategy; one that can accommodate the many complex challenges presented by this new era of competition between Russia, Europe and the United States.

The Author

Andrew Monaghan is Director of Research on Russia and Northern European Defence and Security, The Changing Character of War Centre, Pembroke College, University of Oxford.

Reviews

“A brilliant and hugely enjoyable book. Cogent, well researched and cleverly argued, Monaghan’s illuminating analysis serves as a timely reminder of the dangers of misunderstanding Russia and an “antidote” to Russian stereotypes that prevail in the West.” – Nazrin Mehdiyeva, St Antony’s College, Oxford

“An aggressive, revanchist Russia and the return of Great Power competition make this book required reading.  Monaghan’s extensive knowledge of Russian history, politics, language, and culture give him insights that are crucial to understanding Russia and finding a way back to some sort of normal relationship between Russia and the West.” – LTG (Ret) Ben Hodges, Center for European Policy Analysis

“Dealing with the Russians provides a fresh, informed, and rational approach to solving the problems that arise when nations attempt to deal strategically with the Russian Federation. It will be essential reading for those who prefer to master history rather than fall victim to it.” – David M. Glantz, Carlisle, PA

Behind the Seams at Paul Stuart: Javier Suarez

If you aren’t familiar with Paul Stuart, it is a men’s and women’s clothing brand based in New York City that was founded by Ralph Ostrove in 1938.

Behind the brand’s success is its most helpful team, that in which includes Javier Suarez.

Suarez, who is the Creative Director for men’s shoes and belts, was first appointed to position last August. With him, he’s brought several decades of experience, along with genuine relationships with key manufacturers for the industry in Italy and England.

He started his career with Bally of Switzerland and then Cole Haan, that in which soon led to him spending the next 27 years launching and growing the men’s shoe business of Salvatore Ferragamo.

He brings a unique and rare sense of style to shoemaking, especially in the current retail climate where quantity is unfortunately valued over quality.

What’s different that he does is that unlike larger footwear companies that rely on factory machines, Javier prefers the artisanal families that turn his work dream into reality.

“The strength of Italian production is the wealth of craftsmanship, the people and families that have been doing this forever,” Javier says.

As an expert in shoe design and making, he brings his talent to a comprehensive narrative to Paul Stuart.

“It’s a wardrobe of shoes: we carry the Paul Stuart customer from his work day to his weekend, and on to special formal occasions. It’s a complete collection of footwear with the same characteristics and quality craftsmanship the brand is so well known for in our tailored clothing,” he continues.

His inspiration on the new collection to was the evolution of the iconic nature of the Paul Stuart Style where the standard style were renewed to fit today’s tastes in fashion.
“Shapes, materials, and designs are kept classic but updated to keep up with a modern contemporary sensitivity,” he adds.

Javier’s absolute favorite styles from the collection are The Monaco and The Bandaccio. The Monaco is a brogue wedge sole suede oxford that works perfectly for work and play with super comfort and sharp style. As for the Bandaccio, it is a double buckle zippered combat boot that is handcrafted and has a hand custom polished bravura with “combat” ready Goodyear construction.

Javier believes that the direction in today’s men wear surrounds the idea of innovation–less formality and street wear. “We offer a wardrobe of shoes from casual sneakers to formal wear, keeping a keen eye on a Paul Stuart style sensitivity…it’s again more about the expectation and needs of the consumer than trends for the sake of trends,” he shares.

When asked about the collection and how it ties in with the apparel collection at Paul Stuart, Javier states that the collection connects with everything they do in apparel.

“Paul Stuart’s as a destination for fine tailoring now offers a complete range of innovative elegant and unique dress styles in a coordinated color palette. Antiqued calf, textured grain leathers and sophisticated suede colors compliment the use of texture and color in tailored clothing and sportswear,” he says.

Since 1938, Paul Stuart has been the leading arbiter of taste and style for luxury menswear and womenswear here in the U.S. Celebrating its 80th anniversary this year, the brand outstandingly continues to design and create an exclusive collection of men’s and women’s tailored clothing, sportswear, and accessories.

 

 

Isaac Gracie’s Debut Album

Isaac Gracie’s highly anticipated, self-titled debut album is out now via Virgin EMI/Republic Records. 

 

The album was largely produced by Markus Dravs at RAK Studios in London and features eleven tracks, including Gracie’s recent tracks, “Last Words,” “Terrified” and “The Death of You & I.” See the full tracklisting below.

 

Of his debut album, Gracie says, “Over the course of the two years it took to complete this record, I learnt more about myself and about music than I had in the entirety of my prior life. It was the biggest test I’ve ever undertaken and a winding journey that I won’t forget. To now have the record as a physical representation of a heavy and formative time in my life, that can be traced and re-remembered through listening to it, is an awesome and unique reward for the time and effort and love that was spent.”

 

In celebration of the album, Gracie is set to embark on a UK tour throughout April, followed by a European tour throughout May. See the full list of show dates below. Tickets are available now here.

 

23-year-old London-raised singer-songwriter Isaac Gracie has been finding his feet, working out who he is and discovering what he wants since the industry spotlight fell on him. The fuss was caused by a dusty-sounding, careworn home recording of “Last Words” that was uploaded online without expectation and any anticipation of what was to follow. The voice behind it was completely new to the premise of where writing a great song might lead him. Even now he’d tell you that he’s still slowly working it all out, but this debut collection sounds as fully-realized and confident as any of recent memory. Isaac Gracie is a new British voice, poetic in his placement of words and accomplished in their delivery.

 

Listen to Isaac Gracie here

 

Watch a live Mahogany session recording of “Last Words” here

 

Isaac Gracie Tracklisting:

1. “Terrified”

2. “Last Words”

3. “The Death of You & I”

4. “Running on Empty”

5. “Telescope”

6. “That Was Then”

7. “When You Go”

8. “Silhouettes of You”

9. “All In My Mind”

10. “Hollow Crown”

11. “Reverie”

 

Isaac Gracie Live:

April 13th – The Mash House, Edinburgh

April 15th – King Tut’s Wah Wah Hut, Glasgow

April 16th – The Crescent, York

April 17th – Leadmill 2, Sheffield

April 18th – The Rescue Rooms, Nottingham

April 20th – O2 Institute2, Birmingham

April 21st – O2 Academy2, Oxford

April 22nd – Arts Centre, Norwich

April 23rd – Thekla, Bristol

April 25th – The Haunt, Brighton

April 26th – Hackney Empire, London

April 28th – Le Printemps de Bourges Festival, Bourges

April 29th – Le Petit Bulletin Festival, Lyon

April 30th – Papiersaal, Zurich

May 2nd – Café de la Danse, Paris

May 4th – YUCA, Cologne

May 5th – Kranhalle, Munich

May 6th – ISC, Bern

May 8th – Bi Nuu, Berlin

May 9th – Lille Vega, Copenhagen

May 11th – Gleis 22, Munster

May 12th – Molotow, Hamburg

May 13th – De Oosterpoort, Groningen

May 15th – Club Nine,Groningen

May 16th – Doornroosje, Nijmegen

May 17th – Muziekgieterij, Maastricht

May 18th – AB Club, Brussels

 

ISAAC GRACIE: WEBSITE | FACEBOOK | INSTAGRAM | TWITTER