Posts tagged with "Innovation"

illustration by Sara Davidson for use by 360 Magazine

Hirschvogel at IAA Mobility in Munich

The automotive industry is in a state of upheaval. The demands on mobility are changing. This is a development that Hirschvogel, as a global automotive supplier, is actively addressing. Jörg Rückauf, who has been CEO of the Group since July 1 and who will assume responsibility for Future Business, says: “The mobility industry is undergoing a transformation. We want to take advantage of the resulting opportunities and help shape the change together with our customers.”

Hirschvogel, a family-owned steel and aluminum processing company headquartered in Denklingen, Upper Bavaria, has been systematically expanding its range of products and services over the years. In the automotive industry, it is moving into innovative products that are independent of the combustion engine. At the same time, the company is opening up to new sectors in the mobility environment and investing in other business areas by acquiring stakes in technology companies. These efforts have resulted in the generation of a partner ecosystem.

This year’s IAA Mobility in Munich will see Hirschvogel exhibiting for the first time together with some of those ecosystem partners. Under the name “Hirschvogel Mobility Network”, they will be presenting components and services for mobility concepts of the future. Among the partners present: Eatron Technologies, a specialist for intelligent software in electric and self-driving mobility concepts; Usaneers, experts for the development of innovative human-machine interfaces for the automotive industry; Automotive Synergies, supplier of electronic systems for passenger cars and commercial vehicles; and the Hirschvogel Innovation Center, which coordinates the innovation projects.

Developed for the short haul

The centerpiece of the Hirschvogel Mobility Network’s presence at the IAA will be the new AXIMO (derived from the Latin words for axis and movement), with which it is breaking into the micro-mobility market. AXIMO combines the expertise and services of the individual ecosystem partners to form a component platform for three- or four-wheeled micromobiles. The platform, which encompasses forged and machined components as well as operating displays and software applications, is a modular system. The modules can be used on the customer side to implement different concepts for micro-vehicles in a cost-efficient way. At the IAA Mobility, a delivery robot and a cargo bike will be showcased as application examples.

Tailored to E-mobility

In the automotive supply industry, the Hirschvogel Mobility Network has a growing portfolio of components for E-mobility. These encompass heat sinks for power electronics which, as forged components, demonstrate improved thermal conductivity. Other product highlights include stator housings and ready-for-assembly rotor shafts for electric motors in micromobiles, passenger cars or commercial vehicles, as well as forged and machined electric transmission shafts for passenger cars and trucks. In conjunction with the differentials and components for half shafts that have likewise been added to the portfolio, Hirschvogel can thus cover the entire electric powertrain.

Independent of the powertrain concept

These ready-for-assembly differentials and differential bevel gears expand the range of Hirschvogel components that are independent of the powertrain concept. An augmented reality presentation will make their advantages tangible for the audience at the IAA Mobility. Another focal point will be the chassis. Here, arms and struts, steering knuckles as well as wheel carriers made of forged aluminum will be presented. Compared with cast aluminum, their forged counterparts demonstrate improved mechanical properties and, as lightweight components, help reduce vehicle weight.

“Mobility is becoming more diverse. So is the range of products and services at Hirschvogel. We want to support our customers with suitable components and services when it comes to designing and implementing their mobility concepts. In so doing, we bring our manufacturing know-how–and gladly also our design expertise–to the table,” says Rückauf.

The Hirschvogel Automotive Group

The Hirschvogel Automotive Group is one of the largest manufacturers of forged parts made of steel and aluminum worldwide. As a development partner for modern mobility concepts, with a focus on the automotive industry, and as a production specialist in forging and machining, the core competencies of Hirschvogel include powertrain applications based on all drive technologies, as well as transmissions and chassis in passenger cars and commercial vehicles, and components in off-highway applications. Together with its network of partner companies, Hirschvogel is also active in the fields of electromobility, micro-mobility and software. 

Hirschvogel is an independent family company and has approx. 5,700 employees worldwide. Total sales in 2020 amounted to 1.04 billion euros. The headquarters of the Group are located in Denklingen, Upper Bavaria. Likewise located there are Hirschvogel Umformtechnik GmbH and its parent company Hirschvogel Holding GmbH. The Group is also represented in Germany with three other plants based in Schongau and in Marksuhl, near Eisenach. Internationally, the Hirschvogel Automotive Group is present on three continents: in Gliwice (Poland), in Sanaswadi (India), in Pinghu near Shanghai (China), in Columbus/Ohio (USA) and in San Juan del Río/Querétaro (Mexico).

illustration by Samantha Miduri for use by 360 Magazine

Scuderia Ferrari × Dynisma – New Simulator

Scuderia Ferrari Mission Winnow’s new simulator is completed

The new Scuderia Ferrari simulator is in its new home. The fitting out of the facility and the commissioning of the simulator was completed this week in a new building that sits between the main office of the Gestione Sportiva and the Fiorano Track. In the coming weeks, the calibration work will be carried out and then, at some point in September, after the summer break required by the sporting regulations, the real work will begin, supporting the design phase of the 2022 car.

The new simulator is absolutely at the cutting edge in the field of vehicle dynamics simulation and reproduces in a 360° environment, the lowest latency, and the highest bandwidth motion cueing of any motion simulator available on the market. It is based on a completely new concept– the result of a collaboration between Scuderia Ferrari and Dynisma, a UK-based independent company headed up by former Ferrari engineer Ash Warne. It has been developed exclusively for the Maranello team.

“Simulation and digital technology are going to play an ever more important role in the development of a Formula 1 car and we believe we have made the best possible choice, focusing on creating a tool that will enable us to make a generational leap in this sector,” commented Gianmaria Fulgenzi, Scuderia Ferrari‘s Head of Supply Chain. “To produce it, we chose Dynisma, a young and dynamic company. It has taken two years to complete this project and now we are ready to start using it on the 674 project, which is the name given to the car that will be produced based on the new technical regulations that come into force in 2022.”

Ash Warne, Dynisma CEO said: “All my experience in Formula 1 informed me that motion simulators were just not realistic or responsive enough. We set up Dynisma to change that and with the mission to create the world’s most immersive simulator and widen access to the best high fidelity, responsive motion generators that drivers and engineers could want.

“We are proud that our first commission is for the world’s most famous and respected motorsport team and it’s proof that Dynisma has created world-leading technologies. We have broken convention and redefined the sector by looking at the problem in an entirely new way.”

About Dynisma

Dynisma, an independent company, was founded in 2017 by experienced F1 driving simulator engineer Ashley Warne, who previously led the simulator development efforts of both Ferrari and McLaren. Dynisma has developed a unique approach to high performance motion generation. Dynisma’s range of Motion Generators (DMG’s), feature high bandwidth, low latency, and large excursion motion simulation, delivering class leading driving simulation capabilities.

For more information and to register your interest visit here.

Read the full Scuderia Ferrari statement here.

Fireworks by Mina Tocalini for 360 Magazine

Independence Day Must Haves

Tangy Floral Spritz

The biggest birthday party of the summer is right around the corner and Cavit Wines knows the perfect way to celebrate! Toast to America with a refreshing cocktail that sparkles and shines like the fireworks on the Fourth of July. Below you will find a super easy recipe featuring Cavit’s bright and fruity Prosecco that can be made in under 5 minutes!

Serves: 2

Ingredients:

  • 4 oz (1/2 cup) grapefruit juice
  • 2 oz (1/4 cup) Chase Elderflower Liqueur
  • Ice cubes
  • 6 oz (3/4 cup) Cavit Prosecco
  • 2 grapefruit wedges
  • 2 edible flowers

How to mix:

Divide grapefruit juice and liqueur between 2 glasses; fill glasses with ice cubes; top with Prosecco. Garnish each serving with grapefruit wedge and an edible flower.

Tip: Edible flowers can be found in gourmet food markets in the produce section with herbs or can be ordered and purchased online.

Cavit Wines' Tangy Floral Spritz via Kayleigh Dietz at Berk Communications for use by 360 Magazine

1800 Coco Swizzle

With the summer solstice right around the corner on Sunday, June 20th, cocktail enthusiasts will be looking for delicious, interesting new cocktails to pass the time on the longest day of the year. Fortunately, 1800 Tequila offers the perfect mix of summer tequila cocktails made with their 1800 Silver, 1800 Cristalino, and 1800 Coconut expressions – ideal for unwinding during long summer days, whether enjoyed on vacation or kicking back after a long work week! Please find below three solstice-ready 1800 cocktails and links to purchase 1800 Silver (Drizly & ReserveBar), 1800 Coconut (Drizly & ReserveBar), and 1800 Cristalino (Drizly & ReserveBar).

  • 2 oz. 1800 Coconut
  • ¾ oz. fresh lime juice
  • ¾ oz. simple syrup
  • 6-8 muddled fresh mint leaves 
  • 2 oz. club soda

Directions: In a cocktail shaker, muddle mint leaves before adding the remaining ingredients (sans club soda) and shaking with ice. Pour into a Collins glass over fresh ice and top with soda. Garnish with a mint sprig.

1800 Coco Swizzle 1800 Tequila image via Vaughn Lowery for use by 360 Magazine

Soul Insole Gel Insoles

Who says adorable sandals or flip flops can’t provide foot support? Say goodbye to foot pain and hello to comfort thanks to Soul Insole. This company which makes memory gel insoles that are designed to relieve foot, back and other body pain and gently guide the foot into proper alignment.

You can’t even see these insoles in sandals or flip flops, as they stick to any surface and are clear. They can easily be removed and washed too. Soul Insole gel insoles are perfect for summertime footwear. For more info, please visit Soul Insole’s website.

Soul Insole image via Lindsay Jorgenson for use by 360 Magazine

Absolutely Gluten Free’s Snacks

Absolutely Gluten-Free’s new look and feel across all products better reflects the new and delicious line of sweet and savory items that hit the market. The new line includes an assortment of scrumptious, sweet, and savory snacks that are 100% Certified Gluten-free, all-natural, OU certified kosher, grain-free, free of corn and rice, vegan, and made with only clean and wholesome ingredients. 

Whether you choose a gluten free lifestyle for health, lifestyle or wellness reason, the gourmet, innovative and flavorful Absolutely Gluten Free line of snacks and treats are perfect every gluten-free occasion.  Stock up for Independence Day with the line of Absolutely Gluten Free, which includes crackers and flatbreads, Coconut Chews, and macaroons. For more info, visit their website, Facebook, and Instagram.

Absolutely Gluten Free snacks image via Stacey Bender at Bender PR Group for use by 360 Magazine

E.Cuarenta’s Sparkling Tequila Sunrise

This refreshingly delicious cocktail is great to sip on at cook-outs and picnics. The Sparkling Tequila Sunrise starts with Bay area rapper Earl “E-40” Stevens’  E. Cuarenta tequila mixed with orange juice, then topped off with prosecco and Grenadine. The cocktail is perfect for a hot summer day. 

Sparkling Tequila Sunrise:

  • 2 oz of Tequila
  • 3 oz of orange juice
  • ¼ oz of Grenadine
  • Earl Stevens Selections Prosecco

Method: Add tequila and orange juice into a shaker, add ice, and shake. Pour into a champagne flute and add grenadine slowly. Top with prosecco. Garnish with orange slice.

Walden Farms

Walden Farms just relaunched their amazing zero calorie, zeros fat, zero sugar and zero carbs products. These products sound too good to be true, but Walden Farms has found a way to deliver healthy and delicious dips, spreads, sauces, dressings, condiments, syrups, and coffee creamers.

For those looking to replace their favorite unhealthy dressings with guilt-free alternatives, try Walden Farm’s new Ranch Dressing, Thousand Island, or Honey Dijon. Other tasty options include their BBQ Sauce for grilling, Caramel Dip for dessert, and Alfredo Sauce, which is perfect for healthy family dinners. Walden Farms helps customers find nutritious options that don’t compromise taste.

product images via Stacey Bender at Bender PR group for use by 360 Magazine

Mighty Sesame Co. Tahini

Mighty Sesame Co. offers delicious, healthy, creamy tahini. Their newest launch includes the spicy Harissa tahini favor. Tahini can be used on and in so many recipes, such as in vinaigrettes, dressings, and truffles. With a variety of options– from organic tahini, to whole seed tahini to harissa tahini– customers are sure to love this nutrient-dense, high protein sesame paste.

For those looking to stock up on Might Sesame Co’s deliciousness, the company offers the classic Tahini tub. For no-mess meal prep and easy storage, squeeze-able tahini in a bottle is available. Mighty Sesame Co. ensures that their products are sustainably sourced from Ethiopia.

Mighty Sesame Co. product images via Stacey Bender at Bender PR group for use by 360 Magazine

Andrew & Everett Cheese

Andrew & Everett offers all natural, anti-biotic free, non-cloned sourced cheese. Their American cheese stands apart from other brands with it’s uncompromised quality and taste. Customers can order cheese shredded, pre-sliced, grated, or in bricks. The company also offers butter and seasonal cheese balls.

All of the milk in the company’s cheese is sourced from self-sustaining, family-run farms in America’s heartland– promising consumers with high-quality cheese from free range, grass fed cows. Andrew & Everett products are produced in a gluten free facility and contain no preservatives, binders, or fillers.

Andrew & Everett cheese product images via Stacey Bender at Bender PR group for use by 360 Magazine

Indigo Wild Clothing Biodegradable Apparel

Indigo Wild Clothing creates biodegradable clothing and swimwear that is revolutionizing the fashion industry. The brand‘s unique fabric decomposes in less than five years, while most swimwear sits in a landfill for 40–200 years. Indigo Wild Clothing’s fabrics leaves zero chemicals or microplastics behind. Their brand produces zero waste and uses only biodegradable packaging materials.

Indigo Wild’s bathing suits are made for those with active, on the go lifestyles. These handmade, Hawaiian suits are becoming increasingly popular, and were recently showcased at Miami Swim Week 2021. Indigo Wild Clothing’s suits are priced at $65.00, and consumers will feel good knowing that their money is going towards an innovative and eco-friendly brand.

Indigo Wild Clothing bathing suit image via Lindsey Hytrek at ChicExecs Brand Development for use by 360 Magazine
Image courtesy of Purdue News Services for use by 360 Magazine

Purdue Names First Innovation and Entrepreneurship Fellow

Purdue Engineering names first Innovation and Entrepreneurship Fellow, Yung-Hsiang Lu, professor in the School of Electrical and Computer Engineering, has been named the first Innovation and Entrepreneurship Fellow in Purdue University’s College of Engineering. 

A Purdue University professor and innovator who works to inspire the next generation of technology leaders has been named the first Innovation and Entrepreneurship Fellow for the College of Engineering.

Yung-Hsiang Lu, a professor of electrical and computer engineering, has developed several patented technologies and helped his students start their own companies. He is a Purdue Faculty Scholar, Fellow of the Institute of Electrical and Electronics Engineers and Distinguished Scientist of the Association for Computing Machinery.

We move our discoveries in the lab out to the world for impact through patents and commercialization opportunities, Lu said. This new role provides me with a great opportunity to help connect members of our engineering family with resources to move their technologies and research to communities and people in need.

Lu’s appointment comes as the College of Engineering has put a new emphasis on the importance of faculty innovation and commercialization. These entrepreneurial activities can be documented in the formal tenure review process.

Yung is the perfect fit for this position to help connect our College of Engineering with the Burton D. Morgan Center for Entrepreneurship and resources to support entrepreneurship and commercialization, said Wayne Chen, associate dean for research and innovation in the College of Engineering and Reilly Professor of Aeronautics and Astronautics and Materials Engineering. We want to further develop our culture of support for faculty and students who take their research and lab work to the world through patents and startups.

Lu will collaborate with the Purdue Foundry, an entrepreneurship and commercialization hub, and the Purdue for Life Foundation. He has advised several student teams that won business plan competitions and helped a company obtain two Small Business Innovation Research grants.

Everett Berry, a Purdue alumnus who, with Lu, co-founded a company called Perceive, said he remembers fondly the professor’s belief in the ability of undergraduate innovators.

Having seen Silicon Valley inside and out by this point, I know Dr. Lu embodies the best of the entrepreneurial instinct that we celebrate, Berry said. He was my first, and still strongest, inspiration for building hard technology.

Another alumnus and former member of Lu’s research team, Zohar Kapach, started a company called Oqullo. He said Lu helped him realize his love for computer engineering and the opportunities to grow an entrepreneurial career in the field.

I continue to apply my experiences working with Dr. Lu to my daily research work, Kapach said. I was able to apply the knowledge I gained from working with him to raise a substantial seed fund.

Lu continues to work with the Purdue Research Foundation Office of Technology Commercialization to patent inventions. This office operates one of the most comprehensive technology transfer programs among leading research universities in the U.S.

About Purdue University

Purdue University is a top public research institution developing practical solutions to today’s toughest challenges. Ranked the No. 5 Most Innovative University in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery. Committed to hands-on and online, real-world learning, Purdue offers a transformative education to all. Committed to affordability and accessibility, Purdue has frozen tuition and most fees at 2012-13 levels, enabling more students than ever to graduate debt-free. See how Purdue never stops in the persistent pursuit of the next giant leap at Purdue’s website.

Image courtesy of Purdue News Service for use by 360 Magazine

Purdue University Engineer’s Innovate Air Conditioning

By now, it’s well known that circulating outdoor air in buildings is safer than recirculating indoor air. That point was driven home by the pandemic. Problem is, it’s just not cost-effective.

That may soon change. Purdue University engineers have proposed a system that combines new membrane technology with the latest HVAC systems to make 100% outdoor air systems more energy-efficient and economically feasible – especially in warm, humid climates. They say their system could save up to 66% in energy costs for large buildings that choose to use the safer outdoor air.

Previous research at Purdue has shown that HVAC systems (heating, ventilating, and air conditioning) are a key factor in spreading airborne diseases like COVID in indoor environments like office buildings, restaurants and airplanes.

Most people don’t realize the complexity of a modern HVAC system, said James E. Braun, the Herrick Professor of Engineering and director of the Center for High Performance Buildings at Purdue. There’s a specific sweet spot for humidity in an indoor environment — between 40% and 60%. Any drier than that, and people aren’t comfortable; any more humid, and you’re at risk for mold and other problems.

So, simply opening windows is not a solution.

If you introduce outdoor air, the humidity levels of a building can fluctuate wildly. It’s an incredible challenge to maintain the right balance between temperature, humidity, human comfort and overall cost.

In a typical HVAC system, Braun says, almost 40% of the energy is used to dehumidify the air. That makes the heating or cooling of outdoor air even more energy-intensive and costly.

To solve this problem, Braun teamed up with David Warsinger, assistant professor of mechanical engineering, who specializes in using membranes for water filtration and desalination. They have proposed a system called the Active Membrane Energy Exchanger, which integrates specialized membranes into the HVAC system to reduce the energy required to dehumidify the outside air. Large buildings like hospitals could reduce their energy costs up to 66% with such a system, compared to current fully-outdoor air systems.

Their research has been published in Applied Energy.

The membrane is the key, said Andrew Fix, a Purdue doctoral student in mechanical engineering and lead author of the paper. We use membranes that are vapor selective, meaning they only allow water vapor to pass through when a pressure difference is applied but block air. By passing the air over these membranes, we can pull water vapor out of the air, reducing the load on the motors and compressors that run the refrigeration cooling cycle.

To gauge the system’s effectiveness, the team used computer models created by Pacific Northwest National Laboratory of hospitals in different climate conditions. Hospitals are ideal test beds because they are large indoor environments, which often require a higher percentage of outdoor air in their HVAC systems for safety purposes. The computer models showed an overall reduction in energy usage for all locations using the Active Membrane system. The more hot and humid locations – Tampa, Houston and New Orleans – showed the greatest energy savings.

The more hot and humid it gets, the better our system works, Fix said. This is a key finding, because as the climate continues to warm around the world, locations that want to use 100% outdoor air will now be able to economically afford it.

The researchers are working toward building a physical prototype to validate their computer models. But there’s now more at stake than simply saving energy.

I think COVID was a wake-up call for all of us, Fix said. Heating and cooling our buildings is not just a matter of temperature and humidity, but it can actually be a matter of life and death. Hopefully, this work will help to make all of our indoor spaces safer.

Patent applications for this system have been filed via the Purdue Research Foundation Office of Technology Commercialization. This research is supported by the Center for High Performance Buildings at Purdue University (project number CHPB-50-2020).

About Purdue University

Purdue University is a top public research institution developing practical solutions to today’s toughest challenges. Ranked the No. 5 Most Innovative University in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery. Committed to hands-on and online, real-world learning, Purdue offers a transformative education to all. Committed to affordability and accessibility, Purdue has frozen tuition and most fees at 2012-13 levels, enabling more students than ever to graduate debt-free. See how Purdue never stops in the persistent pursuit of the next giant leap at Purdue’s website.

Award Illustration by Heather Skovlund for use by 360 Magazine

Michael E. Jordan – Entrepreneur of the Year Finalist

From very humble beginnings, Michael E. Jordan has elevated the UNRL brand with core values, quality of product, and a spirit of giving back to the community.

UNRL announced that its founder and CEO, Michael E. Jordan, has been selected as a finalist for the prestigious Entrepreneur of The Year® Award, Heartland Region, presented by Ernst & Young. Based in St. Paul, Minnesota, UNRL is an athletic apparel brand that specializes in creating functional athletic clothing.

After an intensive nomination and selection process, Jordan was identified as one of 36 finalists within the seven-state Heartland region. This award honors game-changing business leaders who rise above challenges using ingenuity, courage, and ambition. Nominees are evaluated based on six criteria: entrepreneurial leadership; talent management; degree of difficulty; financial performance; societal impact and building a values-based company; and originality, innovation, and future plans. 

Jordan founded UNRL in his mother’s basement seven years ago with an investment of a mere $300 and has since grown the company exponentially year after year. Today, UNRL has 19 employees and is on track to reach 8 figures in annual sales. All of this was done with hard work and entrepreneurial spirit, without any outside investment or business loans. 

UNRL products are sold in various retailers throughout the country including Scheels Sporting Goods, PGA Tour Superstore, various NHL, and NFL Pro Shops. One of their most notable apparel partnerships is with the social media powerhouse Barstool Sports. UNRL takes great pride in the quality of their product and their attention to how business is operated. 

“It’s an incredible honor to be selected as a finalist for this award,” said Jordan. “I don’t view this as an individual achievement, this is a testament to my team. It’s been a collective effort with 100% buy-in from every member of our team. Without that, we wouldn’t be here today. I believe we are growing this business the right way, and it is meaningful to be recognized for that. I’m very grateful for all the support Ernst & Young has provided throughout this process.”

Jordan said that he has high expectations for the UNRL brand in the future; articulating plans to surpass the $10 million annual revenue marker within 12 months and reach the $100 million milestone by 2029. In doing so, continuing to donate 15% of net proceeds to nonprofits including the University of Minnesota Masonic Children’s Hospital.  

“I am very competitive by nature. I’ve been an athlete my whole life,” said Jordan. “I pride myself on continuous improvement and doing things the right way to leave a positive legacy on the industry. The Entrepreneur Of the Year® Award has my respect because it’s a challenge against the best in the business, and we have something to prove. I want to win this.”

Regional winners of the Entrepreneur of the Year Award will be announced in late July. The National Entrepreneur of the Year Award will be handed out on November 13.

ABOUT THE ERNST & YOUNG ENTREPRENEUR OF THE YEAR AWARD:

Entrepreneur Of the Year® is the world’s most prestigious business awards program for unstoppable entrepreneurs. These visionary leaders deliver innovation, growth, and prosperity that transform our world. The program engages entrepreneurs with insights and experiences that foster growth. It connects them with their peers to strengthen entrepreneurship around the world. Entrepreneur of the Year is the first and only truly global awards program of its kind. It celebrates entrepreneurs through regional and national awards programs in more than 145 cities in over 60 countries. National Overall winners go on to compete for the EY World Entrepreneur of The Year™ title. 

ABOUT UNRL:

UNRL is a clothing brand that bridges the gap between functional and casual. Their clothing is designed to take you from the office to the gym, or the airport to the golf course. UNRL creates all products with three principles in mind: style, comfort, and versatility. Everything is crafted from scratch with premium hand-selected materials and tailored for a great fit. UNRL is here to instill confidence in the athlete that strives to do more. 

Image of Telescope via Gabrielle Archulleta for Use by 360 Magazine

Osteoporosis: New Approach to Understanding Bone Strength

Innovative Research Reveals Genes That Influence Osteoporosis

 

Researchers at the University of Virginia School of Medicine have taken a new approach to understanding how our genes determine the strength of our bones, allowing them to identify several genes not previously known to influence bone density and, ultimately, our risk of fracture.

 

The work offers important insights into osteoporosis, a condition that affects 10 million Americans, and it provides scientists potential new targets in their battle against the brittle-bone disease.

 

Importantly, the approach uses a newly created population of laboratory mice that allows researchers to identify relevant genes and overcome limitations of human studies. Identifying such genes has been very difficult but is key to using genetic discoveries to improve bone health.

 

“Genome-wide association studies have revolutionized the identification of regions of the human genome that influence bone mineral density. However, there are challenges to using this information to help patients, such as identifying the specific genes involved. Additionally, such studies have focused only on bone mineral density, although many other aspects of bone contribute to bone strength and risk of fracture but cannot be measured in humans,” said Charles Farber, PhD, of UVA’s Center for Public Health Genomics and Department of Public Health Sciences. “The ability to use mice in a novel way has allowed us to begin to overcome the challenges associated with human genome-wide association studies.”

 

Understanding Osteoporosis and Bone Strength

 

Genome-wide association studies have identified more than 1,000 locations on our chromosomes where genes are found that influence bone mineral density (BMD), a strong predictor of how likely an individual is to experience a bone fracture. But bone mineral density is only one factor in bone strength. Farber and his colleagues wanted to get a more complete picture.

 

They created a resource by collecting information on 55 different skeletal characteristics in hundreds of mice and then used an approach called systems genetics to analyze the data. The analysis identified a total of 66 genes that contribute to BMD, including 19 not previously linked to BMD.

 

Of the 19, the researchers were able to determine that two, SERTAD4 and GLT8D2, likely affect bone mineral density through cells that form bone called osteoblasts. This ability to determine the cell types that genes use to perform biological processes is one of the great strengths of systems genetics analysis, the researchers say.

 

The scientists also found that another gene, QSOX1, plays an important role in determining the mass and strength of the outer, “cortical” layer of bone. This type of bone makes up 80% of our skeleton and is vital for bone strength and weight-bearing.

 

In addition to providing new insights into osteoporosis, the new findings highlight the tremendous potential of using mice to identify important genes in humans, Farber says.

 

“The information we generated from mice can be used in the future to evaluate these newly identified genes as potential drug targets,” said Basel Al-Barghouthi, of UVA’s Center for Public Health Genomics, who led the analysis. “Furthermore, these approaches can be applied across a wide range of diseases.”

 

Findings Published

 

The researchers have published their findings in the scientific journal Nature Communications. The research team consisted of Al-Barghouthi, Larry D. Mesner, Gina M. Calabrese, Daniel Brooks, Steven M. Tommasini, Mary L. Bouxsein, Mark C. Horowitz, Clifford J. Rosen, Kevin Nguyen, Samuel Haddox, Emily A. Farber, Suna Onengut-Gumuscu, Daniel Pomp and Farber.

SmartWorldOS screenshot provided by Steve Philp and City Zenith for use by 360 MAGAZINE.

Cityzenith x Digital Twin Consortium

Cityzenith is bringing its city de-carbonization expertise to the Digital Twin Consortium (DTC).

The DTC is a collaborative organization driving the Digital Twin industry forward through a membership drawn from innovators and companies across many sectors.

Its latest invitee Cityzenith has created a software platform, SmartWorldOS™, able to create virtual replicas of buildings, cities and infrastructure to track, manage and optimize carbon emissions to minimize environmental damage.

DTC executive director Dr. Richard Soley welcomed Cityzenith’s membership: “Its specialized knowledge and experience in clean cities will benefit our members greatly as we deploy Digital Twin enabling technologies in buildings, cities, and urban areas.”

Cityzenith CEO Michael Jansen believes DTC membership can take his company to new heights:

“The opportunity to network with fellow Digital Twin market leaders, ground-breaking industry innovators, and the biggest names within the data, technology and construction sectors is game-changing for Cityzenith. This membership will open many doors for us.”

The DTC’s global network not only advances Digital Twin innovation across many industries, but also coalesces sector, government, and academia to drive consistency in vocabulary, architecture, security, and interoperability of the technology.

Members benefit from collaboration with industry peers, participation in industry working groups, influencing requirements and future standards for Digital Twins, and recognition as a Digital Twin industry leader.

Founding members include Bentley, Microsoft, and Dell Technologies, as well as up-and-coming Digital Twin innovators. Cityzenith will chair a working group for DTC, working with other market leaders specifically to the industry’s best interests.

Jansen’s mission at Cityzenith is to use its SmartWorldOS™ software platform to decarbonize cities as part of its international ‘Clean Cities – Clean Future’ campaign in support of the UN-backed Race to Zero initiative.

“Despite only covering 3% of the Earth’s surface, cities contribute to 70% of global carbon emissions while consuming 78% of the world’s primary energy, of which we waste 67.5%,” said Jansen.

“Smart tech innovations such as SmartWorldOS™ can provide the essential interconnectivity required to reduce these percentages, it’s like Sim City but in real life, providing real data to solve real problems.”

“The platform’s ability to handle massive data streams harnessed to cutting-edge AI, has delivered custom climate resilience applications to greenfield cities, real estate developments, and infrastructure projects. We know the issues and have the capabilities to help solve them for those who design, build, and manage cities.”

To hear more from Cityzenith CEO Michael Jansen, please join an upcoming FREE investment webinar, ‘Join The Race to Zero – Investing in Technology For Sustainable Cities’ taking place virtually on Tuesday8th June at 08:00 CT and 13:00 CT. To learn more about using emerging tech to combat Climate Change, please sign up here.

Art by Heather Skovlund for use by 360 Magazine

Million Dollar Listing: Ryan’s Renovation

BRAVO GETS TO WORK WITH FOUR-EPISODE LIMITED SERIES “MILLION DOLLAR LISTING: RYAN’S RENOVATION” ON JUNE 3RD AT 10:15PM ET/PT  

Bravo brings Greek traditions to Brooklyn in the new limited series Million Dollar Listing: Ryan’s Renovation premiering Thursday, June 3 at 10:15pm ET/PT. After purchasing a multi-million-dollar townhouse for their expanding family, Ryan Serhant and wife, Emilia, gut the newly acquired 7,900 square foot home to create the home of their dreams with enough room for their big Greek family. In each episode, viewers will see the transformation of the constantly evolving townhouse, with more than a few hiccups along the away.

While the vision for the vast, five-floor property started as a home for daughter Zena to grow up in, it’s expanded into an inn for the couples’ extended family. Embracing Emilia’s very large Greek family, they are building out the basement level as a suite for Ryan’s mother-in-law…but with mom comes dad, sister, brother, and the rest of the family. Since everyone wants a room, everyone wants their opinions heard. With so many voices chiming in, the Greek chorus starts to sound like chaos.  

In a renovation of this magnitude, there are always bumps and curveballs, including COVID-postponements, elevator installations, questioned decisions, and millions spent over budget. In an empty, concrete shell of a property, can Ryan see a forever home to grow old in, or will the chaotic, expensive construction make an unexpected multi-million dollar offer worth considering?     

 Watch a sneak peak right here

Million Dollar Listing: Ryan’s Renovation is produced by World of Wonder with Randy Barbato, Fenton Bailey, Tom Campbell, Nick Prescott and Kevin Maynard serving as Executive Producers.  

About Bravo 

Bravo is the premier lifestyle and entertainment brand that drives cultural conversation around its high-quality, interactive original content across all platforms. The network features a diverse slate of original programming, including Emmy Award-winning Top Chef and Project Runway fan-favorites Vanderpump Rules, Below Deck, Southern Charm, and the highly popular Million Dollar Listing and The Real Housewives franchises. Bravo also boasts the only live late-night talk show on television with the critically acclaimed Watch What Happens Live with Andy Cohen which has become a nightly destination for A-list celebrities. Bravo is part of the NBCUniversal Television and Streaming portfolio, which includes NBCU’s broadcast, cable and streaming platforms: NBC, Bravo, E!, Oxygen, SYFY, Universal Kids, USA Network and Peacock. For more information, visit Bravo’s website

'Homme 277' NFT illustration by Heather Skovlund for 360 Magazine

HOFA Gallery NFT Artworks

HOFA Gallery NFT artworks will appear alongside corresponding physical artworks at London exhibition this week

Press preview in gallery and virtually: Thursday 13 May 2021, 10.00 – 18.00 (BST)  

As the NFT artwork phenomenon continues to expand the boundaries of collectible art, HOFA Gallery is boldly reprising their role as pioneers with the upcoming release 15 May release of NFT artworks as digital complements to physical works currently on display in the ‘Matter & Form’ exhibition. 

The planned press preview will take place at HOFA Gallery, Mayfair on Thursday 13 May 10.00 – 18.00 (BST) in gallery or virtually by appointment (photographers and videographers welcome).  

Jan KalabLoribelle SpirovskiGregory Siff and Darian Mederos, four widely celebrated feature artists in HOFA’s latest group exhibition, will release their crypto artworks on via a special collaboration with MakersPlace – the world’s largest art NFTs marketplace.  This move bridges the perceived gap between conventional art and digital art and is part of HOFA’s ongoing effort to put contemporary art within reach of today’s younger, tech-savvy art collectors. 

HOFA Co-founder Elio D’Anna says “Traditional, conventional art has always struggled with the problem of accessibility, which meant that many people were excluded from enjoying and investing in art. Furthermore, it has meant that artists could only reach a fraction of their potential audience.” 

He continues Finally, the world of digital is steadily levelling the field, and today we are seeing the NFT phenomenon address this problem of accessibility in a new way by giving legitimacy and currency to digitally subsisting art.

In 2018, HOFA made headlines when it became the first to embrace the possibilities of blockchain-powered cryptocurrency by making their entire art holdings available for purchase using Bitcoin and Ethereum. Along with innovative partners, HOFA also helped established the world’s first digital asset-based art investment platform which enables full and partial investments in blue-chip contemporary artworks using secure blockchain technology to authenticate and record transactions.  

HOFA Co-founder Elio D’Anna sums up “By embracing the world of collectible NFT art, both the gallery and our emerging and established contemporary artists can exponentially expand their reaches.  We are finding these new audiences, consisting mainly of Millennials and Gen Zs, are enthusiastic about art and keen to have digital-first art experiences that are easily personalized and conveniently accessible via smart devices.”

Press preview: ‘Matter & Form’ at HOFA Gallery, Mayfair on Thursday 13 May 2021, 10.00 – 18.00 (BST), in gallery and virtually by appointment only.  

In compliance with Covid-19 safety protocols, all visits to the gallery will be strictly on RSVP basis.

Matter & Form video

HOFA Gallery Website

HOFA Gallery Instagram

‘Homme 277’ NFT by Loribelle Spirovski drops on MakersPlace 15 May 2021
‘Breathing Turkis Lagoon’ NFT by Jan Kalab drops on MakersPlace 15 May 2021
 ‘Games of Youth & Legend’ NFT by Gregory Siff drops on MakersPlace 15 May 2021