Posts tagged with "alcohol"

Nick Offerman x St. Patrick’s Day

Nick Offerman Wants You To Get Ready For St. Patrick’s Day Now – And Guinness Is Here To Help

Follow the Guinness Countdown to St. Patrick’s Day and Get Tips from Offerman and Others on What to Wear, Eat, Drink and More for the Best St. Patrick’s Day Ever

He can act. He can sing. He can make you laugh, and he can make you cry. He can even build you a bar – among other things – with his bare hands. What Nick Offerman apparently can’t do is bide his time, which is why he’s teaming up with Guinness to give you an entire month to get ready for his favorite day of the year – St. Patrick’s Day – with the official Guinness Countdown to St. Patrick’s Day. Spoiler alert: green beer will not be making an appearance.

“Look, St. Patrick’s Day is easily the best of the holidays, and I will brook no argument to that assertion,” said Offerman. “The charismatic folks at Guinness know a thing or two about how to celebrate my favorite day. You’ll be able to see it all on Instagram, but if I had to nutshell it, I’d say gather with your family and your friends, both old and new. Eat some delicious meats, like corned beef – straight up or in a hash – wash it down with a pint of Guinness, then wash the Guinness down with some more corned beef. A glass or two of water along the way never hurt either.”

Starting now, everyone over the age of 21 looking to celebrate the holiday like a pro can follow along with Offerman on Instagram at @GuinnessUS for daily reveals of tips, tricks, trivia and suggestions on everything from how to pour the perfect pint of Guinness to what foods pair best with that pint to how to give an authentic Irish toast and much, much more.

As St. Patrick’s Day should bring out the best in everyone, the countdown will also cover how to give back; now through March 31st, share your Guinness ‘stache using the hashtag #StacheForCharity and tag @GuinnessUS, and Guinness will donate $1 to the Guinness Gives Back Fund*.

Guinness is even helping those celebrating to dress for the occasion with the new Guinness x Carhartt collaboration. United by the spirit of hard work and master craftsmanship, this collection includes everything from tees to hoodies to hats and more. The entire line is available for a limited time now at Carhartt.com/Guinness – where fans over 21 can also enter for the chance to win the trip of a lifetime to visit the Guinness Storehouse in Dublin until March 1st**.

“The countdown to March 17th is on, and we hope that our own countdown can add a little something to the St. Patrick’s Day experience,” said Guinness Brand Director, Nikhil Shah. “As long as you’re celebrating with a Guinness and the people you love, and having a good safe time, you can’t go wrong.”

Celebrations will also continue at the Guinness Open Gate Brewery in Baltimore. In honor of its second St. Patrick’s Day since officially opening in August 2018, the home of Guinness in the U.S. will kick off weekend celebrations on March 14th and 15th with an Irish Village experience, an Irish beer tap take-over, pop-up entertainment, limited-edition merchandise, a holiday-themed food menu and more. More details are available at www.guinnessbrewerybaltimore.com.

For all the Guinness Countdown to St. Patrick’s Day happenings, follow along at @GuinnessUS on Instagram, Twitter and Facebook. And remember, whether you’re planning to celebrate St. Patrick’s Day at the pub or at home with family and friends, the only way to raise a pint is responsibly.

*Up to $100,000. Visit stacheforcharity.com full details. The Guinness Gives Back Fund is a corporate donor advised fund administered by Fairfield County’s Community Foundation. The Fund’s mission is to support local charitable organizations.

**NO PURCHASE NECESSARY. A PURCHASE WILL NOT INCREASE YOUR CHANCES OF WINNING. LEGAL RESIDENTS OF THE 50 UNITED STATES (D.C.) AND CANADA (EXCL. QC) 21 YEARS AND OLDER. VOID IN QC AND WHERE PROHIBITED. Promotion begins January 14, 2020 & ends March 1,2020. For Official Rules, how to enter, prize descriptions and odds of winning, visit www.carharttsweeps.com. If Canadian resident, mathematical skill-testing question must be correctly answered to win. Promotion consists of random drawing sweepstakes & instant win game. 3 sweepstakes prizes and 144 instant win game prizes (approximate retail values from $25 to $13,100 USD) available to be won. Trip prize winner’s guest must be 21, alcohol is not included & trip must be completed by 12/31/2020. Instant win game prize winners subject to verification. Sponsor: Carhartt, Inc., 5750 Mercury Dr., Dearborn, MI 48126 U.S.A.

About Guinness
The Guinness brand was established in 1759, when Arthur Guinness signed a 9,000 year lease on St. James’s Gate Brewery in Dublin. Brewed using four main ingredients, water, barley (malted & roasted), hops and yeast, Guinness is the world’s most popular stout. The iconic beer is brewed in 49 countries worldwide and sold in over 150 with almost 9 million glasses of Guinness enjoyed every day around the world. The most GUINNESS is sold in Great Britain, Ireland, USA, Nigeria and Cameroon. More information can be found at www.guinness.com.

About Diageo
Diageo is a global leader in beverage alcohol with an outstanding collection of brands including Johnnie Walker, Crown Royal, Bulleit and Buchanan’s whiskies, Smirnoff, Cîroc and Ketel One vodkas, Captain Morgan, Baileys, Don Julio, Tanqueray and Guinness.

Diageo is listed on both the New York Stock Exchange (DEO) and the London Stock Exchange (DGE) and our products are sold in more than 180 countries around the world. For more information about Diageo, our people, our brands, and performance, visit us at www.diageo.com. Visit Diageo’s global responsible drinking resource, www.DRINKiQ.com, for information, initiatives, and ways to share best practice.

Follow us on Twitter for news and information about Diageo North America: @Diageo_NA.

Nick Offerman, Guinness, Carhartt, 360 Magazine, Nick Offerman, Carhartt, Guinness, 360 Magazine, Guinness, Nick Offerman, Carhartt, 360 Magazine,

Alcoholism in the Family

Alcoholism in the family affects how your brain switches between active and resting states.

A family history of alcoholism affects a process that the brain uses when transitioning from a mentally demanding state to a resting state, researchers have found.

You don’t have to be a drinker for your brain to be affected by alcoholism. A new study shows that just having a parent with an alcohol use disorder affects how your brain transitions between active and resting states – regardless of your own drinking habits.

The study, performed by researchers at Purdue University and the Indiana University School of Medicine, discovered that the brain reconfigures itself between completing a mentally demanding task and resting.

But for the brain of someone with a family history of an alcohol use disorder, this reconfiguration doesn’t happen.

While the missing transition doesn’t seem to affect how well a person performs the mentally demanding task itself, it might be related to larger scale brain functions that give rise to behaviors associated with addiction. In particular, study subjects without this brain process demonstrated greater impatience in waiting for rewards, a behavior associated with addiction.

Brain-Reconfiguration
Multiple regions of the brain are involved in a “reconfiguration” that happens between completing a difficult task and resting. But for people with a family history of alcoholism, this reconfiguration is diminished.

Findings are published in the journal NeuroImage. The work was led by Enrico Amico, a former Purdue postdoctoral researcher who is now a researcher at EPFL in Lausanne, Switzerland.

How the brain reconfigures between active and resting states is like how a computer closes down a program after you’re finished with it. “The moment you close a program, a computer has to remove it from memory, reorganize the cache and maybe clear out some temporary files. This helps the computer to prepare for the next task,” said Joaquín Goñi, a Purdue assistant professor in the School of Industrial Engineering and the Weldon School of Biomedical Engineering.

“In a similar way, we’ve found that this reconfiguration process in the human brain is associated with finishing a task and getting ready for what’s next.” Goñi’s research group, the CONNplexity Lab, takes a computational approach to neuroscience and cognitive science.

Past research has shown that a family history of alcoholism affects a person’s brain anatomy and physiology, but most studies have looked at this effect only in separate active and quiet resting states rather than the transition between them.

“A lot of what brains do is switch between different tasks and states. We suspected that this task switching might be somewhat lower in people with a family history of alcoholism,” said David Kareken, a professor of neurology at the Indiana University School of Medicine and director of the Indiana Alcohol Research Center.

The study defined a “family history of alcoholism” as someone with a parent who had enough symptoms to constitute an alcohol use disorder. About half of the 54 study participants had this history.

Researchers at Indiana University measured the brain activity of subjects with an MRI scanner as they completed a mentally demanding task on a computer. The task required them to unpredictably hold back from pressing a left or right key. After completing the task, the subjects rested while watching a fixed point on the screen.

A separate task outside of the MRI scanner gauged how participants responded to rewards, asking questions such as if they would like $20 now or $200 in one year.

Amico and Goñi processed the data and developed a computational framework for extracting different patterns of brain connectivity between completing the mentally demanding task and entering the resting state, such as when brain areas rose and fell together in activity, or one brain area rose while another fell at the same time.

The data revealed that these brain connectivity patterns reconfigured within the first three minutes after finishing the task. By the fourth minute of rest, the effect had completely disappeared.

And it’s not a quiet process: Reconfiguration involves multiple parts
of the brain at once.

“These brain regions talk to each other and are very strongly implicated in the task even though by this point, the task is already completed. It almost seems like an echo in time of what had been going on,” Kareken said.

Subjects lacking the transition also had the risk factors that researchers have seen to be consistent with developing alcoholism. These include being male, a greater number of symptoms of depression,
and reward-impatience.

A family history of alcoholism, however, stood out as the most statistically significant difference in this brain reconfiguration.

The finding affects research going forward.

“In the past, we’ve assumed that a person who doesn’t drink excessively is a ‘healthy’ control for a study. But this work shows that a person with just a family history of alcoholism may also have some subtle differences in how their brains operate,” Goñi said.

This research was funded by the National Institute on Alcohol Abuse and Alcoholism (grant P60AA07611) and the Purdue Discovery Park Data Science Award “Fingerprints of the Human Brain: A Data Science Perspective.” The work was also partially supported by the National Institutes of Health (grants R01EB022574, R01MH108467, and R00AA023296).

About Discovery Park
Discovery Park is a place where Purdue researchers move beyond traditional boundaries, collaborating across disciplines and with policymakers and business leaders to create solutions for a better world. Grand challenges of global health, global conflict and security, and those that lie at the nexus of sustainable energy, world food supply, water and the environment are the focus of researchers in Discovery Park. The translation of discovery to impact is integrated into the fabric of Discovery Park through entrepreneurship programs and partnerships.

Bud Light x Super Bowl x Post Malone

BUD LIGHT CALLS ON FANS TO HELP CHOOSE THE SUPER BOWL COMMERCIAL FEATURING POST MALONE

Bud Light Goes Inside the Brain of its #1 Fan, Post Malone, as he Stars In Two New Commercials for Bud Light and the Newly-Launched Bud Light Seltzer

NEW YORK, Jan. 29, 2020 — Today, Bud Light unveiled“#PostyStore” and “#PostyBar”, two new spots featuring Bud Light Seltzer and Grammy-nominated Bud Light fan, Post Malone. Instead of a traditional launch, the brand is opening up their biggest marketing moment of the year to the fans. Bud Light made two funny ads featuring Post Malone and cannot decide which one to take to Super Bowl LIV as their official in-game commercial. Now the brand is looking to their fans to share their input and help determine which commercial will air in the big game.

Starting this morning through Thursday, January 30, fans can visit Bud Light social channels to watch both commercials and share their input to help Bud Light make the decision on which advertisement to feature during Super Bowl LIV. Fans will need to tune in to the big game to learn which one Bud Light decided on.

“It feels cool to be in a Bud Light commercial, especially a Bud Light Super Bowl commercial, which is a huge deal,” said Post Malone. “I just love the taste and the camaraderie. So it’s a real honor and blessing for me to be able to be a part of such a big moment.”

Both advertisements take you into the brain of musician and Bud Light enthusiast, Post Malone. “#PostyStore” shows Post inside a convenience as he faces a decision a predicament: does he purchase his go-to drink Bud Light or the new Bud Light Seltzer? This predicament sparks confusion and mayhem in Post’s brain, and the store. Ultimately, he remembers that he’s rich and can afford to purchase both – who doesn’t love a happy ending? The second spot,“#PostyBar” follows Post Malone into a bar where he discovers Bud Light Seltzer Mango. Post goes in for a sip and his senses begin to determine what it tastes like, how it smells and if he likes it. Just like the rest of America, Post Malone and his taste buds give Bud Light Seltzer Mango his seal of approval.

“We are so fortunate to have two great Super Bowl spots this year, but only have room for one. We love this year’s Super Bowl campaign because not only does it feature our brand’s biggest fan, Post Malone, but we’re also giving people a chance to help us choose which spot to air,” said Andy Goeler, VP of Marketing for Bud Light. “Bud Light Seltzer offers another easy-drinking option that aligns with what our fans know, love and expect from Bud Light. We’re thrilled with the consumer response on the product so far and are excited to bring it to the Super Bowl stage with Post. The situation that plays out in Post’s head is one that many consumers might have too, but don’t worry, just like Post, you can get both Bud Light and Bud Light Seltzer too.”

“#PostyStore” and “#PostyBar”continues the campaign behind the Bud Light Seltzer narrative, previously introduced in the recent commercial “The Message” which ran during the NFL Playoffs, leaning into consumer’s questions of what is a hard seltzer and the difference between Bud Light and Bud Light Seltzer.

Bud Light Seltzer offers an easy-drinking hard seltzer with a hint of delicious fruit flavor to deliver the most refreshing taste possible. It is 100 calories, 5% ABV, has <1g of sugar and comes in four great flavors – black cherry, mango, lemon lime and strawberry.

To learn more about Bud Light go to www.budlight.com or follow Bud Light on Facebook, on Twitter at @BudLight and on Instagram at @BudLight

6 Tips for Serving Alcohol at Your New Year’s Eve Party

Saying good-bye to an old year and welcoming in a new year full of possibilities is a great occasion to pull out your cocktail glasses and favorite cocktail recipes. Whether you insist that your guests dress in their best for your party or your focus is on comfort and a friendly gathering, there are several things you can do to make sure everyone is having a great time.

One: Arrange Rides Ahead of Time

When you plan a party knowing that you’re serving a lot of alcohol, plan ahead. Make sure you have your phone fully charged and that you’ve saved the numbers to your favorite cab companies. You may want to book a cab or two ahead of time unless you don’t mind having a guest crash at your home overnight.

Two: Choose One or Two Cocktails

Serving a full bar can quickly become very expensive. When you want to serve cocktails, limit your offerings to one or two drinks. If guests want something else, you could have wine and beer available. Keep things fun by offering an array of unique and festive garnishes.

Three: Serve Food

A sweet cocktail is a fun way to help your guests get comfortable but serving them in addition to some fun snacks or a meal is a good way to save money and cut down on the next day’s hangovers. A full range of appetizers or hors d’oeuvres can reduce the amount of alcohol you go through and may prevent guests from becoming too inebriated.

Four: Figure Out How Much Alcohol You Need

Your New Year’s party will come to an unhappy end if you run out of food and drinks. Make sure you have plenty of alcohol by considering how many people will attend, how long the party should last, and whether the drinks are the primary focus or just a side attraction. As you make your calculations, give yourself a bit of wiggle room by getting extra ingredients.

Five: Establish Limits

It’s a good idea to avoid becoming very drunk yourself, so you’re able to recognize if one of your guests is making dangerous decisions. You may need to find rides for guests or make decisions about whether a guest should continue drinking. At some point in the night, stop serving your New Years Eve cocktails and switch to soft drinks, tea, or coffee. You may want to hire a professional bartender to help you with this part of the night.

Six: Brush Up on Local Laws

Even if you’re serving alcohol in your home, there are laws that could affect you. Make sure you’re familiar with liquor licensing and service laws in your area. If you’re not sure where to find information about these laws, contact your insurance provider. Protect yourself from “dram shop liability” or social host liability. If you serve alcohol and one of your guests injures someone else, you could be held responsible.

Hosting a party to celebrate a brand-new year is a great way to get your friends and family together. Make sure everyone enjoys themselves and gets home safely by choosing a good selection of drinks and food and by considering the safety of your guests.

alice in chains, Warner Music Artist, recording artist, celebrity, 360 MAGAZINE, Illinois, spirits, bourbon, tequila

ALICE IN CHAINS × FEW SPIRITS

A.S.K. AND UNLOCK THE SECRETS: FEW SPIRITS, SEATTLE GRUNGE LEGENDS ALICE IN CHAINS COLLABORATE ON ALL SECRETS KNOWN, 101-PROOF BOURBON FINISHED IN TEQUILA BARRELS

“For us distilling, like making music, is about having the courage to ASK, ‘What if we…’ and being excited to find the answers – unlocking those secrets.” – Paul Hletko, Master Distiller, FEW Spirits

FEW Spirits and Warner Music Artist Services announce today the release of All Secrets Known, a new, limited-release bourbon distilled by FEW Spirits Master Distiller Paul Hletko in collaboration with Grammy-nominated and multi-platinum selling Seattle Grunge pioneers Alice In Chains, whose music has stood the test of time and influenced a generation. Bottles feature a custom-designed label by artist Justin Helton.

The Whiskey
All Secrets Known (SRP: $75/750 ml), a nod to the name of the opening track of Alice In Chains’ 2009 certified Gold release Black Gives Way To Blue, is FEW Bourbon finished for six months in tequila barrels and bottled at the most rock and roll of proofs, 101 (50.5% ABV). Bold, sweet, and spicy bourbon top notes that have become the hallmark of FEW and led to multiple category awards, are accentuated by grassy agave undertones.

Said Hletko, “There are no two spirits that have a closer association with rock and roll than whiskey and tequila. Bringing together elements of both, but in an unconventional, innovative way, is an illustration of what we try to do every time we distill a new product.”

The Collaboration
“Alice In Chains is part of one of very few movements that can be legitimately credited with shapeshifting an entire culture, beginning with their first album, Facelift,” continues Hletko. “For us distilling, like making music, is about having the courage to ASK, ‘What if we…’ and being excited to find the answers – unlocking those secrets. Nobody sounds like Alice In Chains. We were inspired by their courage to create a sound that flouted convention and thought, ‘There are lots of tequilas finished in bourbon barrels, but it’s rare to find a widely-available bourbon finished in tequila barrels. Let’s do that instead’.”

Added Matt Young, EVP of Warner Music Artist Services, “Our team always seeks out the best in the business when it comes to our artist product collaborations. FEW Spirits was a no brainer when the idea first came up to create an Alice In Chains Bourbon Whiskey.”

The Label Design
Artist Justin Helton, of Status Serigraph, is no stranger to working with musical giants like Phish, The Avett Brothers, My Morning Jacket, Ween, and The Black Keys created the custom label.

“I’ve been a fan of Alice In Chains forever with Jar of Flies being one of the first CD’s I ever owned,” says Helton. “‘I Stay Away’ and ‘No Excuses’ were on repeat in my room. For this design I found inspiration in the name All Secrets Known. The eye in the mouth is a play on seeing all that’s been spoken. The color scheme is a nod to Black Gives Way to Blue, the album on which the song ‘All Secret Known’ appears.”

Helton designed the label in Adobe Illustrator and Photoshop, also using a mix of hand-rendered illustrations with imagery from the 1800’s to create a distinct look.

A Legacy of Rock and Roll Partnerships
All Secrets Known is yet another foray for FEW Spirits into partnerships with internationally-renowned music acts. In 2006, Hletko partnered with The Flaming Lips to create Brainville Rye Whiskey.

“Brainville led to access,” Hletko said. “Doors started opening and I’ve always felt like when you get a chance to work with cool people you admire, you’ve got to at least check it out. As a long-time fan of Alice In Chains and someone who has at various points made his living as a guitar player, the opportunity to work with someone like Jerry Cantrell, whose sound is unlike any other, was one we were determined to see through come hell or high water.  

Limited-release All Secrets Known will be available in CA, CO, IL, NY, and WA and for purchase online through ReserveBar.com.

Find FEW Spirits:

  • Online: www.FEWspirits.com 
  • IG, FB, Twitter: @FEWspirits
  • Hashtags: #FEWspirits, #FortuneFanciesTheBold, #FEWask

About FEW Spirits
A grain-to-glass distillery since 2011, FEW Spirits produces award–winning craft whiskey and gin in a tucked away alley located in the growing Chicago suburb of Evanston, IL.. A historical town where Prohibition lasted until 1972, Founder & Master Distiller Paul Hletko changed the future of Evanston when he opened FEW Spirits Distillery, the first (legal) alcohol-production facility of any kind to ever open there.

Paul Hletko always knew he wanted to make craft spirits —produced in the local Chicago area—that offered something different, delicious and fun. Living in Evanston, a town that was prime for change after being dry for four decades post the repeal of prohibition, Paul felt it was the perfect home and backdrop for FEW and the brand. Deeply integrated into the brand story, both Evanston and Chicago are crucial elements of the FEW DNA and its inspiration. From its liquid, created from locally grown or sourced ingredients, to the look & feel of the design, which pays homage to the 1893 World’s Fair in Chicago— FEW is the true definition of a local Illinois craft spirit.

FEW Spirits features a refreshing and innovative portfolio including a stable of core spirits and several small batch limited edition specialty expressions. Each flagship spirit is a new take on the timeless liquors of the past; distilled from the very best grains, aged to perfection, and bottled under the FEW roof. The small batch limited editions hold true to the premium quality FEW drinkers have to come to love and expect from the brand, but offer something novel to the oft-ordinary taste and style we’ve all grown accustomed to.

In a world over saturated with mass-produced spirits, only few remain truly handcrafted, locally sourced and small-batched. FEW has never strayed from this—even as it grows, Paul and his team continue to provide consistently impeccable spirits that are true to their craft roots and reminiscent of their home base.

About Alice In Chains
Seminal rock band ALICE IN CHAINS recently toured in support of RAINIER FOG, which hit No. 1 across Billboard’s Rock, Alternative and Hard Music Charts and No. 1 on the iTunes Rock Album Chart and earned them a Grammy nom for “Best Rock Album.” Over the course of their remarkable career, ALICE IN CHAINS (vocalist/guitarist Jerry Cantrell, drummer Sean Kinney, bassist Mike Inez and vocalist/guitarist William DuVall) have garnered multiple Grammy nominations, sold more than 30 million albums worldwide, and amassed a diehard international fanbase whose members number in the millions.

Their discography features some of the biggest and most important albums in rock history, including 1992’s quadruple-platinum-certified “DIRT,” 1994’s triple-platinum-certified EP JAR OF FLIES, which was the first EP in music history to debut at No. 1 on the Billboard Top 200 and 1995’s self-titled double-platinum-certified ALICE IN CHAINS, which also entered the Billboard Top 200 at No. 1. They returned in grand style in 2009 with the critically acclaimed BLACK GIVES WAY TO BLUE, which hit No. 1 across the rock and alternative charts, earned a Grammy nomination, was certified Gold and hailed by Vice as “a record that’s as powerful as anything the band has done.” ALICE IN CHAINS remains one of the most successful and influential American rock bands of all time.

Binge Drinking May be More Damaging to Women

Alcohol consumption is a major cause of chronic liver disease in the United States, and binge drinking is emerging as a significant contributor to liver injury. According to the Centers for Disease Control and Prevention, one in six U.S. adults binge drink four times per month. In a recently published study examining the effects of binge drinking on rats, researchers from the University of Missouri School of Medicine discovered that female rats who were of equal age and weight to male rats were more sensitive to alcohol and experienced alcoholic liver injury at a higher rate than male rats.

“Some chronic drinkers can drink for several years and still live relatively healthy lives,” said Shivendra Shukla , PhD, Margaret Proctor Mulligan Professor of medical pharmacology and physiology at the University of Missouri School of Medicine . “But many chronic drinkers are susceptible to liver damage when they binge drink. The liver is the metabolic powerhouse of the body and liver injury can compound damage to other organs. We studied the similarities and differences of gender-specific responses to repeat binge drinking. Our research showed just three binge drinking episodes triggered a response for more injury in the female rats.”

Shukla found a statistically significant difference using just four male and four female rats, giving them the same amount of alcohol three times at 12-hour intervals. He collected and analyzed blood and liver tissues four hours after the last binge episode. Shukla discovered the blood alcohol concentration was twice that in the female rats, but not all damage in males and females reflected that ratio. He discovered the female rats had nearly 4 times as much fatty build-up in the liver, a trigger for additional inflammation and damage.

“There’s a protein called diacylglycerol kinase-alpha (DGKa) that has been shown in other studies to promote tumor growth and cancer,” Shukla said. “In our findings, this protein goes up 20% in male rats, but increases 95% in females. However, any role this protein plays in alcohol-induced breast cancer is unknown and remains to be investigated in the future.”

Shukla says additional studies in humans will be needed to further understand the potential differences in how binge drinking affects males and females, and the metabolic causes for these differences. “Unfortunately, alcohol has been glamorized,” Shukla said. “It is dangerous. Don’t binge drink. The research is very clear.”

In addition to Shukla, the study authors include Ricardo Restrepo, PhD, Annayya Aroor, PhD, Robert Lim, PhD, Ronald Korthuis, PhD, and Xuanyou Liu, graduate student from the Department of Medical Pharmacology and Physiology at the University of Missouri School of Medicine; and David Ford, PhD, and Jacob Frank, graduate student, Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research at Saint Louis University.

The study, “Binge alcohol is more injurious to liver in female than male rats: histopathological, pharmacological, and epigenetic profiles,” was recently published in the Journal of Pharmacology and Experimental Therapeutics. The authors of the study declare that they have no conflicts of interest.

7 Things To Give Up To Help You Get Pregnant This Year

by Mary Jane Minkin, MD, Clinical Professor of OB/GYN at Yale University

Unfortunately, a simple do-it-yourself plan doesn’t exist, but fertility specialists and women’s health experts agree that certain measures can create the best possible chances for fertilization to occur. So, without ironclad guarantees, here are 7 things to give up to help you get pregnant this year:Every couple mired in infertility, every woman who has ever spent hours scouring the Internet for new breakthroughs and conception tips has had the same wish: For a clear-cut, easy-to-follow program that would guarantee a healthy pregnancy. 

    • Alcohol. Studies focusing on alcohol’s effect on conception have produced mixed results, with some indicating that pregnancy is more likely if women give up drinking entirely and others suggesting that those who drink moderately might increase their chances of conception – perhaps because an occasional glass of wine makes them more relaxed. But experts agree that women who give up alcohol will increase their chances of a healthy baby once conception does happen, and that alone is reason enough for most women to quit.

 

    • Tobacco. Unlike alcohol, the data smoking’s correlation to pregnancy is undisputed. Both primary and secondhand smoke are detrimental to a woman’s chance of conceiving and to a developing fetus as well. Quitting is never easy, but resources and support to help you find a plan and stick to it.

 

    • Caffeine. As the daily substance of choice for most Americans, dependency on those morning cups of coffee is difficult to break. Try cutting back on your intake if you drink multiple cups a day- a recent study confirms ACOG guidelines that one standard 12 oz. cup of regular coffee (200 mg of caffeine) is safe for pregnancy. 

 

    • Your Spot on the Couch. In other words, get up and move around! Couch potatoes aren’t helping any aspect of their health, but women who are trying to conceive have an extra-compelling reason to kick it into high gear. Experts agree that women who stay within their ideal weight have a better chance of becoming pregnant, and a study published in Obstetrics and Gynecology reported that women who exercise 30 minutes or more a day had a reduced risk of ovulation disorders, which often lead to infertility.

 

    • Junk food. Generally speaking, any change that moves you toward a healthier lifestyle will promote fertility. But when it comes to diet, advice seems to fall all over the map. Specific fertility diets advocate for eating foods like oysters, garlic and yams, but an extensive 2009 study advised women to follow simpler guidelines – healthy fats, selective proteins, whole grains and plenty of iron and other vitamins. It’s important to start taking supplemental folic acid to help prevent birth defects. The sooner you can start taking a prenatal vitamin with sufficient folic acid like vitafusion, the better! You should begin taking prenatals even before you begin trying to conceive. And, obviously, putting down the potato chips and the candy bars is an excellent first step to take to help you get pregnant this year. 

 

    • Excessive Stress. Granted, this step is easier said than done, especially when the chief cause of the stress is the infertility itself. But if external factors are causing undue anxiety, a woman’s chance at conception can decrease, and the stress of waiting for that positive pregnancy test month after month could be the last straw for her emotional health. Give up extra responsibilities whenever possible, talk to your boss about reducing your job stress and work in regular “mental health” days to be refreshed by activities and people you enjoy.

 

  • Lubricants Containing Glycerin. According to the American Society of Reproductive Medicine (ASRM) “Guidelines for Optimizing Natural Fertility”, several leading vaginal lubricants (e.g. K-Y) may decrease fertility based on their observed effects on sperm survival. Another study showed that lubricants containing glycerin had an adverse effect on sperm motility. Fertility experts recommend using a fertility friendly lubricant like Pre-Seed that is specially formulated without glycerin that will not harm sperm and allows sperm to swim freely. 

Like we said, there is no checklist you can complete that guarantees a healthy pregnancy, but giving up these 7 things can help you get pregnant. It’s all about creating the ideal environment for the pregnancy to happen; a healthy, happy and active lifestyle is a solid base and giving up the aforementioned things will get you there.

Mix Up These Delectable Cocktails For National Tequila Day

If there is ever a food holiday that needs to be celebrate and acknowledged as a national holiday, it is National Tequila Day on July 24. Whether you prefer the sweetness of the Añejo or the smoothness of the Blanco, we have got you covered with flavorful bevvies from margaritas to a spicy beso caliente! Have your own fiesta at home with these five recipes below!

Cardamom Margarita

INGREDIENTS

2oz of Cardamom-infused DeLeon Platinum tequila

1oz lime juice

.5oz Gum Syrup

PREPERATION

Infuse 10 grams of cardamom in a 750 ml bottle of DeLeon Platinum for 20-30 minutes.

Add ice, 1oz lime juice, 0.5oz gum syrup, and 2oz of cardamom-infused DeLeon Platinum in a shaker.

Strain & serve.

Garnish with a cardamom pod.

GLASSWARE

Margarita

GARNISH

Cardamom seeds

DeLeon Paloma 

INGREDIENTS

1.5 oz DeLeon Reposado tequila

1 oz grapefruit juice

.75 oz lime juice

.5 oz simple syrup

Pinch of Kosher salt

Club Soda

PREPARATION

Shake all ingredients with ice & strain over fresh ice into glass.

Top with Club Soda

GLASSWARE

Highball/Collins glass

GARNISH

Grapefruit wedge

Twisted Maria

INGREDIENTS

1.5oz DeLeon Platinum tequila

1oz Watermelon Juice

3 Cherry tomatoes on Vine

.5oz Lime Juice

1tsp Agave

PREPARATION

Mull 3 cherry tomatoes in a shaker

Blend 3-4 pieces of watermelon or 1oz of watermelon juice into a shaker

Add in remaining ingredients and pinch of salt

Shake, strain and pour over ice

GLASSWARE

Rocks Glass/Collins

GARNISH

Lime Wedge and Tomato

Raspberry Sour

 

INGREDIENTS

1.5oz DeLeon Añejo

.75oz Lemon

.5oz Simple syrup

4-5 muddied raspberries

PREPARATION

Muddle raspberries in a shaker, add remaining ingredients and strain over a coupe

GLASSWARE

Coupe

GARNISH

Raspberries on a cocktail pick

Beso Caliente

 INGREDIENTS

1.5oz DeLeon Reposado tequila

.75oz lemon juice

1 oz simple syrup

4-6 dashes Angostura bitters

PREPARATION

Shake first three ingredients with ice & strain into a small coupe glass

Float Angostura bitters

GLASSWARE

Either small coupe glass or rocks glass over ice

Six Ways to Cut Down on Alcohol

by Tara Yombor, LMHC and clinical director at Pathway to Hope, a Delphi Behavioral Health Group facility.

Social (moderate) drinking, binge drinking, alcoholism, tolerance, and dependence. This is the typical pattern of progression for drinking that leads someone to think of him or herself as needing to cut down on alcohol. Some might think they are prone to alcoholism. Within that progression, the time for someone to cut down on drinking is based on the individual’s idea of what is causing dysfunction and unmanageability in their life.

Why is it so easy for someone to become addicted to alcohol, and what does it mean to have
an alcohol use disorder?

First of all, alcohol does not have an adverse social stigma, which makes the dependence for it more likely, and the consumption of it more acceptable. Alcohol is typically used to celebrate happy events and sooth the sad events in life. Think about a celebration. What do most people imagine? Alcohol, champagne, and a “toast to the New Year!”

During times of mourning or stress, alcohol can be used to ease the emotional pain of a loss or as a stress reliever. Social (or moderate) drinking is seen as a normal and perfectly harmless way of socializing, relaxing, or a form of celebration.

A binge drinker is defined as a man who drinks more than four to six drinks in a two-hour period, and a woman who drinks more than four to five drinks in a two-hour period. Someone with alcohol use disorder is typically a person with a long-term addiction to alcohol. This person is typically unable to control how much they consume or when to stop drinking and spends a lot of time thinking about the next drink.

It can be easy for someone to transition from a social drinker to a binge drinker to having an
alcohol use disorder. A binge drinker is someone who has more than the above allotted
acceptable drinks in a short amount of time.

Someone who is a binge drinker or struggling with heavy alcohol use may find that people close to them begin to notice negative patterns of behavior during times of drinking. Friends and family may start to become worried about the person’s drinking patterns and negative outcomes that have begun to arise from their drinking. A person who begins to engage in
binge drinking may find themselves calling out of work the day after drinking due to a hangover; they may miss important deadlines, get into arguments with their loved ones, or lose track of daily responsibilities.

Tolerance for alcohol means that a person needs more and more alcohol to feel the desired effect than they previously would not have needed. Someone who has a pattern of binge drinking may find themselves drinking even more alcohol in a short time to feel drunk.

Once tolerance increases, the possibility of dependence increases. Dependence can be defined as relying on alcohol to avoid withdrawal symptoms. Essentially, a person is controlled by their need to ingest alcohol to feel “normal.”

During any of these stages of alcohol use, someone may feel the need to seek treatment. The need for treatment varies for each person based on how dysfunctional or unmanageable their life has become due to their drinking.

Here are six things you (or anyone) can do to cut down on alcohol. Most of these mean a change in behavior.

1. Acknowledge the problem – in order to stop the behavior, you must first acknowledge what the negative behavior is and make a conscious effort to commit to changing that behavior. Also, put the goal in writing and make a list of reasons why you want to cut back on drinking. For example, if the behavior is drinking too much during celebrations, you have to determine what “too much” means to you and, next, set a goal to decrease the amount you are drinking during celebrations.

2. Set a realistic goal for drinking alcohol – if you struggle with binge drinking, set a realistic, and achievable goal. The next time you’re out during a social event, make it a goal to cut back to three to four drinks in two hours instead of five to six. Or perhaps instead of going to a happy hour on Friday or Saturday night, pick one night to go out and stay in the other night. Cutting back by making realistic and achievable goals will keep you on track and make you feel better about the fact that you are keeping your goals.

3. Write it down – make sure to keep a journal of the times you drink, how much you drink, and any negative outcomes related to the times you drink (for example, drinking and falling down or making an inappropriate comment to a friend). By keeping a journal, you will hopefully be able to see patterns of behavior. You can also share this journal with someone you trust and ask them to look out for any patterns you may have missed.

4. Don’t keep alcohol in your house – it is easier to come home after a long day of work and pour a glass of wine rather than going out to the bar on a Wednesday when you may have other obligations at home such as taking care of a child. When you don’t have alcohol in the house, it eliminates the desire or temptation to drink.

5. Stay busy – by having non-alcohol related activities to engage in, you are more likely to say no to drinking, as you’ll want to be present for the activity. Do things that keep you active, such as riding a bike, hiking, going for a walk as the endorphins from engaging in exercise may eliminate the desire for alcohol.

6. Ask for support/Talk to someone – tell people you trust about your goals and ask them to help keep you accountable during times when you may be struggling or find yourself surrounded by temptation. Also, there are therapists who specialize in alcohol/substance use who you can talk to that can assist you with your goals and process through any underlying emotions that may be related to drinking.

Remember that the above tips may not work for everyone. Some people may be into the stage of alcohol tolerance and dependence. If you or someone you love is struggling with alcohol dependence, reach out for help from a professional or call a treatment center in your area. Alcoholism and dependence look different for everyone.

Santa Monica Pride Bar Crawl

June 22 is officially the day to be gay in Santa Monica. Join us in painting our town with color at the FIRST EVER Santa Monica Pride Bar Crawl, hosted by iHeart Radio/HereTV’s On the Rock’s Alexander Rodriguez. The crawl encourages crawlers to love proudly and drink responsibly at some of Santa Monica’s most fabulous bars while raising money for the Los Angeles LGBT Center.
This exciting inaugural event kicks off on the historic Santa Monica Pier where the first 50 participants will receive a complimentary Kona Beer or Whiteclaw at the Pier 360 Paddleboard Race Beer Garden. From there, crawlers will shantey their way through the streets of downtown Santa Monica under miles of rainbow lights, sip on pride drink specials at participating locations and end at the official after party “Club Love” at 1212 Restaurant on the Third Street Promenade with The Abbey’s DJ Brynn Taylor, disco ball dance party, photo booth, and more.
Pride Crawl participants are encouraged to dress as freely as they wish to fully decorate the streets of Santa Monica with every color of the rainbow. There will be glitter face painting and flags and SaMo Pride swag passed out at the starting/check-in location. An Instagram costume contest will award the crawlers with the most impressive gear with special prizes (#SaMoPrideCrawl).
Participating locations include: Rusty’s Surf Ranch, 1212 Santa Monica, Barney’s Beanery, Cabo Cantina, Makai, Ye Olde King’s Head, Red O & Britannia who will have a karaoke party. 
Where: Check-in will take place at the Pier 360 Paddle Board Races Check-in booth. (200 Santa Monica Pier). 
Time: Registration is from 3pm – 6pm, crawl goes until 2am
When: Saturday, June 22nd 
Tickets: Tickets are $10 in advance and available at samopridecraw