Posts tagged with "clinical studies"

COVID-19 Trial Tests if Common Drug Can Keep Patients Out of Hospital

At-risk people diagnosed with COVID-19 across the United States and Canada can participate in a clinical trial testing whether a common drug can keep them from getting sicker and keep them out of the hospital.­­

The trial, conducted by Washington University School of Medicine in St. Louis, is based on a discovery by the University of Virginia School of Medicine’s Alban Gaultier, PhD, and a former graduate student, Dorian A Rosen, PhD.

Gaultier and Rosen found last year that the antidepressant fluvoxamine may stop the deadly inflammation known as sepsis, in which the immune response spirals out of control. The drug’s apparent benefit for dampening dangerous inflammation prompted the Washington University researchers to begin investigating its potential benefit for COVID-19, which can also cause dangerous overreactions of the immune system.

“If this clinical trial is proven successful, fluvoxamine could become a standard treatment for patients newly diagnosed with COVID-19, especially patients at risk,” Gaultier said. “Even the best vaccines do not protect 100% of the population, and discovery of safe and affordable treatments to prevent COVID-19-associated complications is critical.”

Fluvoxamine and COVID-19

Earlier this year, the Washington University researchers launched their first clinical trial of the drug in patients with COVID-19. That trial compared fluvoxamine with a harmless placebo in 152 adult outpatients. None of the 80 participants who received fluvoxamine became seriously ill after 15 days, while six patients who received placebo did. Of those six, four were hospitalized, for periods ranging from four to 21 days. One was on a ventilator for 10 days.

Based on those initial results, Washington University is now launching a much larger trial open to residents across the United States and Canada. The trial is seeking approximately 880 at-risk participants, age 18 and older, who have tested positive for COVID-19 and are experiencing mild symptoms.

Participants will be provided with either fluvoxamine or a placebo for approximately 15 days. No face-to-face contact is required; everything necessary will be sent to the participants’ doorsteps.

Contactless Check-Ins

The researchers will track the patients by videochat, email or telephone to determine if fluvoxamine provides a benefit and helps keep participants out of the hospital. During brief daily check-ins, trial participants will report their oxygen levels, blood pressure and temperature, along with whether they are feeling shortness of breath or have had any other problems.

The study team will continue to follow the participants for approximately 90 days after they have finished taking fluvoxamine or the placebo.

The trial is open to people who have at least one risk factor for severe COVID-19, such as being 40 or older, being part of a high-risk racial/ethnic group (such as African-American, Hispanic, Native American or biracial), or having one or more medical conditions such as obesity, diabetes, high blood pressure, heart disease, a lung disease or an immune disorder such as rheumatoid arthritis.

For more information about the trial, visit this website.

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PUR ATTITUDE™ LAUNCHES ADVANCED CELL RENEWAL NIGHT CRÈME 

 

An Overnight Skincare Product with Natural Polymer Time-Released Technology, Bio-Advanced Peptides and Fermented Oil

 

PUR attitude™  released Advanced Cell Renewal Night Crème, a high-performance anti-aging cream that delivers key ingredients into the skin overnight via a natural polymer time-released technology. The cream also leverages bio-advanced peptides that oxygenate the skin and promote cell renewal, and fermented oil to improve youthful suppleness of the skin.

 

“The beauty of the PUR attitude brand is that we can deliver such advanced technology using safe ingredients,” said Jerry Rayman, President of PUR attitude. “The science behind anti-aging skincare is developing at a rapid rate. The products have better performance than ever before. PUR attitude is delighted to deliver yet another high-performing product to the marketplace.”

 

Advanced Cell Renewal Night Crème is enhanced with the power of natural Hyaluronix™ technology, which delivers up to one thousand times its weight in water, binding moisture deeply into the skin. This night cream uses a complex of three different molecular weights of Hyaluronic Acid—combined with glucosamine and ceramides—to create a delivery system that encapsulates and time-releases key ingredients deep within the lower layers of the skin. The cream also delivers a bio-advanced peptide technology along with Acetyle Hexapeptide-3, which has been proven to help reduce the signs of aging.

 

While the health benefits of eating fermented, probiotic foods are widely accepted in the food industry at this time, their use in skin care is relatively new. Fermenting natural oils restructures complex molecules, transforming them into tiny “superfoods” for the skin, providing faster absorption that results in healthier, younger-looking skin. Advanced Cell Renewal Night Crème uses a fermented olive oil for superior performance.

 

Each product in the PUR attitude line is dermatologist tested and approved, backed by independent clinical studies, and follows the brand’s standards for “Safe Beauty,” avoiding harsh chemicals, parabens, PEG’s, glycols, sulfates, petro-chemicals, synthetic fragrances and artificial dyes.

 

Advanced Cell Renewal Night Crème is available in 1 fl oz at a retail price of$59. (This is approximately a six-week supply, when used once daily). For more information, visit www.PURattitude.com.

 

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About PUR attitude

Based in Boca Raton, Florida, PUR attitude products contain only safe beauty ingredients and are not diluted with water. More than 1,300 chemicals have been banned from the company’s lab, which adheres to strict EU standards. All formulations for the brand were developed by David Pollock, a beauty innovation chemist with more than 20 years of experience formulating products for some of the most recognized names in the industry.