Posts tagged with "prostate cancer"

Prostate cancer illustration by Heather Skovlund for 360 Magazine

Battle Against Prostate Cancer

New Insights into Hormone’s Action Could Help in Battle Against Prostate Cancer

Discovery Sheds Light on How Cancer Cells Use Androgen

Researchers at UVA Cancer Center have unveiled important new insights into how hormones known as androgens act on our cells – and the discovery could boost efforts to develop better treatments for prostate, ovarian and breast cancers.

The findings shed light on how androgens interact with their receptors inside cells to affect gene activity. This process is important in both healthy cells and certain cancers. Hormone therapy for prostate cancer, for example, aims to reduce the amount of androgen in the body, or to stop it from fueling the cancer cells. However, the approach does not work for some men, and for others it eventually fails. So, scientists are eager to better understand how our cells – and cancer – interact with androgen.

“Our study reveals a new mechanism for how androgen regulates communication within prostate cancer cells,” said Bryce M. Paschal, PhD, of the UVA School of Medicine’s Department of Biochemistry and Molecular Genetics. “Anti-androgen therapies continue to be the cornerstone for prostate cancer therapy. The better we understand how androgens work, the better clinicians will be positioned to understand why it fails, and how even better therapies can be designed.”

Androgen and Cancer

In a new paper in the scientific journal Nature Communications, Paschal and his colleagues describe how a complex signaling system regulates androgen receptor activity. The system, they found, uses a “writer” and a “reader” to modify cellular proteins – sort of like how a computer reads and writes information.

Scientists have appreciated the importance of these modified proteins but understanding just how they influence the androgen receptors has been difficult. One key to the regulation process, found by Paschal and his SOM team, is an enzyme, Parp7, produced by the PARP7 gene. Parp7 is part of a family of enzymes involved in important cellular functions including DNA repair.

Certain cancer drugs already target certain Parp enzymes; these drugs are used to treat prostate, ovarian and breast cancers in patients who have mutations in DNA-repair genes. And while androgens are usually discussed in the context of prostate cancer, androgens may be important in ovarian and breast cancer as well.

Paschal’s new findings offer fresh insights into these Parp drugs and could lead to improved treatments that help patients get the best outcomes. Further, Paschal and his team found lower levels of Parp7 in prostate cancer that has spread to other parts of the body than in the initial tumors. That may suggest that a reduction in Parp7 is associated with the progression of the disease, the researchers say.

With their new androgen insights, Paschal and his colleagues have provided scientists with important new directions to explore in the battle against prostate and other cancers.

“Our next steps will be to use pre-clinical models to determine the role this pathway plays in prostate cancer progression, and whether inhibition of the pathways slows disease,” Paschal said. “We are very excited by what we have learned thus far. Our study emphasizes there is still so much to be learned, and that basic science plays a critical role in defining the molecular context for enzyme and drug action. “

About the Research

The research team consisted of Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton and Paschal.

The work was supported by the National Institutes of Health’s National Cancer Institute, grant CA214872.

To keep up with the latest medical research news from UVA, subscribe to the Making of Medicine blog.

NIC TAYLOR 1 360 MAGAZINE

Nic Tailor

Nic Tailor is a new custom men’s underwear brand, (customizable online), that is changing the game of the undergarment industry by setting a philanthropic standard. The brand was founded by North Carolina natives Cal Mosack and Nolan Mills, along with Audie Cooper, a former designer for Ralph Lauren, taking the lead on the creative.

The trio sought out to create underwear for men made from high quality fabric, that was uniquely fit to your measurements, alleviating any discomfort or the need to adjust due to movement. In September of last year, Nic Tailor partnered with the Prostate Cancer Foundation and Actor Peter Facinelli, for a campaign to raise awareness for prostate cancer. Images of the actor went viral, making headlines as he stripped down to nothing but a pair of Nic Tailors for the campaign; one that hits particularly close to home for the actor, and a cause he is passionate in spreading awareness for.

Nic Tailor’s efforts to raise awareness continues, with a portion of their sales being directly donated to the prostate cancer foundation.  They also just introduced the Dry Fly brief for men who have battled prostate cancer.

The company explains its premise perfectly on its site: “At one time or another, most guys complain about their underwear,” it states. “It never seems to fit quite right because it’s only available in S-M-L-XL sizes. What about your weight, shape, and well, other measurements? Wouldn’t it be great if there were customized underwear? Well now, we figured, with the customizing capabilities of the internet, we could create underwear that is made to your exact size and shape.” Nic Tailor, short for “tailored knickers,” takes into consideration butt size, groin size…everything that makes people different.

“We felt there was a need for a true custom underwear product that was 100 percent made in the USA,” says Audie Cooper.  “If you’re going to pay for a premium pair of underwear you should not be limited to S, M, L, or XL. Our brand is especially great for the guy who sits for long periods of time, athletes, or those guys who have large buns.”

And with prices ranging between $38 and $51, Cooper notes that customers keep coming back for more. For spring, the brand is working on a traditional boxer product versus the boxer briefs it sells now. Cooper also says he is working on developing a new fabric that will allow the brand to offer more color selection and prints.

Stouts N Staches, 360 Magazine

Stouts N Staches

6th Annual Venice Beach Stouts N Staches Returns to Venice on Sunday March 3rd, 2019 at Exciting New Location, Clutch Venice to Raise Awareness for Men’s Health

Brew Fest, Pig Roast, Live Music, Mustache Trims & More at Clutch on Lincoln Blvd.

Stouts N Staches is back for it’s 6th year bringing together the Venice community and local bands for a beer fest fundraiser to raise awareness for the Movember Foundation. Participants will enjoy beer from area breweries and whiskey tastings as well as a Pig Roast from Oscar Hermosillo, owner of Clutch and Venice Beach Wines. This year’s event will take place in the parking lot of Clutch Venice who will be kicking off their own Sunday Pig Roast series and supplying ticket holders with a full plate of their famous BBQ (vegetarian and vegan options will be present). Other options available for guests include wine and non-alcoholic beverages, giveaways, free mustache and beard trims, leather treatments, live music from Bob Dylan Tribute band, Jack of Hearts, cigar lounge, mustache contests and more.

A portion of proceeds from Stouts n Staches will benefit men’s health issues through The Movember Men’s Health Foundation.

Sponsors/Vendors include: Clutch Venice, MedMen, Venice Paparazzi, Dr. Scobi Kombucha, Service & Supply Barbershop and more.

WHEN:

Sunday, March 3, 2019

3-8 p.m.  

WHERE:

Clutch Venice, 427 Lincoln Blvd, Venice, CA 90291

TICKETS:

$15 in advance for GA (access to music, games, access to vendors & more)

$40 in advance for VIP (includes 2 drink tickets, pig roast, whiskey tastings, live music, beard trims and more. Beer and Wine available for purchase.

 

LINKS:

www.stountsnstaches2019.eventbrite.com 

www.stoutsnstaches.com 

www.clutch-venice.com 

ABOUT MOVEMBER FOUNDATION:

The Movember Foundation is a global charity raising funds and awareness for men’s health. These funds deliver breakthrough research and support services to allow men to live longer, healthier, happier lives. Since 2003, millions have joined the men’s health movement, raising more than $650 million and funding over 1,000 programs through impact investments, focusing on prostate cancer, testicular cancer, poor mental health and physical inactivity.  

 

Movember is fully accredited by the Better Business Bureau, and for the past three years, has been named a Top 100 best NGO by The Global Journal. For more information please visit Movember.com. Movember is a registered 501(c)(3) charity.

###

 

@stoutsnstaches

#StoutsnStaches

#Movember

#MensHealth

SEA Blue Prostate Cancer Walk & Run

SEA Blue is a celebration of life, of those who have risen to the challenge to fight prostate cancer, of the lives that have been lost to the disease, and of the people we will help to combat it in the future through Support, Education and Advocacy. The longest running Prostate Cancer event in the Chicagoland area will take place on Sunday, September 9th in Lincoln Park (LaSalle & Stockton), Chicago. The event offers a celebration walk and 5K run.Proceeds from this event benefit Us TOO International Prostate Cancer Education and Support Network providing educational resources and support to the prostate cancer community at no charge. Registration includes talk to the doc prostate cancer education tent with Q&A, Free PSA (prostate specific antigen) testing, Free Lunch and Snacks, Event t-shirt, expanded family fun zone with face painting, jump houses and more, one complimentary beer for those ages 21 and older courtesy of Hofbrauhaus and live music. Event registration is priced at $50 for 5K adult runners, $40 for adult walkers, $30 for 5K child runners, and $25 for child walkers. Participation is free for children six and under. Us TOO International Prostate Cancer Education and Support is a 501(c)3 non-profit organization. We are committed to helping those affected by the disease and this event has played a significant role in raising money and awareness. To register or for any additional information please visit: www.seablueprostatewalk.org

The Good News: Early Diagnosis Is the Key to Curing Prostate Cancer

Movember, named after the world’s largest movement fighting for men’s health, is the time to talk about the good news concerning prostate cancer. “The key to curing prostate cancer is early diagnosis,” says Dr. Dudley Danoff, author of The Ultimate Guide to Male Sexual Health, 2nd edition (Beyond Words, 2017).

There are no symptoms associated with early prostate cancer. The primary tool for early detection of prostate cancer is a screening blood test, PSA (prostate-specific antigen). All men age forty and over should get a yearly screening PSA blood test, as well as a digital rectal examination by a qualified physician. Heightened public awareness, making the early diagnosis of prostate cancer easier, has resulted in an increase in effective treatment and cure.

“The good news is that—provided the diagnosis of prostate cancer is made early enough to allow maximal effective treatment—life after prostate cancer, surgery, or other treatment options can be full, rich, and rewarding and allow a man to be continent, sexually active, and vigorous in all areas of his life,” advises Dr. Danoff.

Approximately 240,000 new cases of prostate cancer will be diagnosed in the United States this year. It is the most common male malignancy and the second most common cause of death from all tumors.

A requested guest on national radio and television shows, Dr. Danoff is a graduate of Princeton University and Yale University Medical School. He taught on the clinical faculty of the UCLA School of Medicine for more than twenty-five years and is the founder and president of the prestigious Cedars-Sinai Tower Urology Medical Group in Los Angeles. Urologist to many Hollywood stars and the recipient of national and international honors, Dr. Danoff is also senior attending urologist at the Saban Los Angeles Free Clinic.

If you need an expert on men’s health issues, including those involving sensitive subjects and tips for a healthy, active sex life at any age, Dr. Danoff is available for radio and television interviews and also has numerous articles available for your immediate use on a variety of topics, including:

4 Treatment Options for Prostate Cancer: A Quick Guide

In the last thirty years, there has been a dramatic increase in the number of cases of prostate cancer detected each year. This is due to the rising median age of our population as well as our ability to detect tumors at an earlier and more curable stage. The good news is that the increase in the number of cases is being met with an increase in effective treatment. If you are diagnosed with prostate cancer, depending on the aggressiveness of the cancer and other health factors, you may have a number of options.

Can Prostate Cancer Be Prevented?

Prostate cancer is one of the most serious health problems in the global community. About one in every six men in the United States will develop the disease during his lifetime. With the dramatic increase in incidence, it’s understandable to want to ask the question, how can I prevent prostate cancer? The truth is, you cannot actually prevent prostate cancer (but you may reduce your risk of prostate cancer by making healthy choices, exercising, healthy diet, prostate massaging, etc.); however, with early diagnosis you can beat the deadly potential of disease.

How to Have a Terrific Sex Life after Prostate Cancer

When patients learn they have prostate cancer, they often fear that impotence is inevitable. In almost all cases, fear of impotence is totally unwarranted. However, it is true that the old surgical cure for prostate cancer left 60 to 80 percent of patients impotent since surgery damaged the vital nerve bundles that make erection possible. Dr. Danoff explains that with modern advances in treatment, you can have a terrific sex life after prostate cancer.

Dudley Seth Danoff, MD, FACS, is a graduate of Princeton University and Yale University Medical School. He has taught on the clinical faculty of the UCLA School of Medicine for more than 25 years and is the founder and president of the prestigious Cedars-Sinai Medical Center Tower Urology Group in Los Angeles. Urologist to many Hollywood stars and the recipient of national and international honors, Dr. Danoff is also senior attending urologist at the Saban Los Angeles Free Clinic.