Posts tagged with "sick"

Kaelen Felix Illustrates a COVID-19 Article for 360 MAGAZINE

Antidepressant x COVID-19

Based on a trial from the University of Virginia School of Medicine, the antidepressant fluvoxamine appears to prevent COVID-19 infections from worsening, even keeping patients out of the hospital.

The clinical trial was conducted by the Washington University School of Medicine in St. Louis. Fluvoxamine was compared with a placebo in 152 adult patients who were infected with the coronavirus.

80 participants received the fluvoxamine, and not one of the 80 became seriously ill after 15 days. Six patients receiving the placebo became seriously ill with four being hospitalized for between four and 21 days. One of the four in the hospital was on a ventilator for 10 days.

Though the sample size was relatively small, the data is believed to be statistically significant. The plan is to launch a larger trial in coming weeks.

Eric J. Lenze, MD, of the Washington University School of Medicine, said patients who took fluvoxamine did not require hospitalization because of issues in lung function.

“Most investigational treatments for COVID-19 have been aimed at the very sickest patients, but it’s also important to find therapies that prevent patients from getting sick enough to require supplemental oxygen or to have to go to the hospital,” Lenze said. “Our study suggests fluvoxamine may help fill that niche.”

UVA’s Alban Gaultier, PhD, and former graduate student Dorian A. Rosen, PhD, found in 2019 that fluvoxamine may stop sepsis, a deadly inflammation causing the immune system to spiral out of control. The findings of Gaultier and Rosen inspired the tests at the Washington University School of Medicine.

Gaultier and Rosen determined that fluvoxamine reduces the production of cytokines, which have been linked to deadly cytokine storms, which are thought to occur in severe cases of COVID-19

“Because elevated cytokines levels have been associated with COVID-19 severity, testing fluvoxamine in a clinical trial made a lot of sense to us,” said Gaultier. “We are still unclear about the mode of action of fluvoxamine against SARS-CoV-2, but research is under way to find the answer.”

Washington University’s Angela M. Reiersen, MD, said the drug works by interacting with the sigma-1 receptor to reduce the production of inflammatory molecules.

“Past research has demonstrated that fluvoxamine can reduce inflammation in animal models of sepsis, and it may be doing something similar in our patients,” Reiersen said.

The limitations of the research were emphasized. The small sample size was noted along with the fact that 20% of participants stopped answering surveys during the trial. Though the researchers could rule out hospital visits for those who stopped answering, they did believe it possible that the participants sought treatment elsewhere.

Because of the limitations, the findings should be considered encouraging and worthy of further research rather than iron clad truth.

Gaultier said, “If a larger clinical trial (phase III) confirms the results, fluvoxamine would be a perfect treatment for COVID patients newly diagnosed. Fluvoxamine is not an experimental drug, it is cheap and safe and could be available as a first line of defense to unburden the hospitals that are overwhelmed by the COVID health crisis.”

For more medical research news from UVA, you can click right here.

How To Treat Dog Chemotherapy Side Effects   

Dogs are often called man’s best friend and we can’t ignore the fact that it’s true. Dogs are one of the most popular pets there is and for good reason: They are adorable. Having dogs is like caring for your kids. You want them to be safe and healthy as possible. Keeping them that way is not always a challenge. 

Some of us find it quite easy. You just feed them, give them a bath, put a roof over their heads, and give them love and care. But sometimes, we don’t always know what’s going on with them, right? You don’t know where they’ve been all day. 

It’s also hard to tell if their sick or not, but you’ll notice how they’re energy decreases. Let’s talk about one of the familiar illnesses a dog might face. And the most common is cancer. 

Cancer is a disease known to all of us and it doesn’t only affect us, humans. It also affects our pets. One of the most common cancers in dogs is lymphoma. This happens when lymphocytes (also known as the white blood cells that fight infection)grow out of control. 

Another cause of cancer is usually long exposure in the sun, second-hand smoke, and even chemicals such as pesticides and herbicides. But I didn’t say it’s not treatable. Your furry friend could continue to live a healthy life if you can treat him/her as early as possible. The most familiar treatment is chemotherapy. 

What Is Chemotherapy?

This is usually given to those with cancer, both humans and pets (such as dogs). They are given drug treatments to help them with their illness. I can’t say that it will cure it entirely, but it does help with slowing down cancer (read more).

Chemotherapy is usually prescribed by a doctor or veterinarian. It is proven to be effective and it will make your dog live longer. Turns out, dogs can withstand this treatment better than humans. If your dog has cancer, the most time he/she has is two months, more or less. But if your pet got diagnosed with cancer a little bit earlier, you can save his life. 

Unlike dogs who had aged, it will more likely lead to death, sad but true. The average time a dog has when it undergoes chemotherapy is 10-12 months or maybe more. There are a lot of bright sides to this but your furry friend will have to face a little pain. You just have to be there for them and care for them properly. 

Even though the doses given to a dog that is on chemotherapy is much lower than what is given to humans, they will still experience the side effects. The side effects will often occur 3-5 days after they are given the therapy, but this will pass. Let me provide you some info about the side effects and these are the following:

  • Vomiting
  • Loss of Appetite
  • Diarrhea
  • Allergic Reaction
  • Urine Color (this shouldn’t make you worry, it is normal.)

Those were just a few types of side effects and all of it will just pass. If you think your pet needs medication to lessen the side effects, first consult a doctor or veterinarian. But you could lessen your pet’s suffering by giving them CBD or Cannabidiol

What Is Cannabidiol?

This is very popular for it gives benefits to those who require its natural remedy. It comes from one of the many chemical substances known as cannabinoids that are from the marijuana plant (Cannabis Sativa).

CBD is known for the benefits it provides for your body and this helps with your pets too! People suggest that using CBD can be very helpful during the treatment of cancer. It’s not proven to be effective in treating cancer but it helps manage the side effects that we talked about earlier. 

The treatment often causes inflammations and that causes pain to your dog. But, with CBD you can help your pet with its suffering. According to this website, https://www.holistapet.com/testimonials-item/using-it-for-chemotherapy-side-effects/, it helps with the loss of appetite, it provides pain relief and may reduce nausea (but this comes from a different compound other than CBD). To make sure, you should ask if it’s advisable but to lessen your doubts, it is legal. 

They use CBD to treat the side effects of our precious fur babies. They can help you in treating your pet and making them feel better! There will always come a challenging phase in their lives and we can’t always protect them from illnesses. 

Just like cancer, it brings them suffering and you must do what you can to make them feel better and relieve them from the pain they are feeling. CBD is recommended. So, if it works for others it might work for you too! Don’t wait for your pet’s last moments, instead, make the moments last longer! 

Grab the opportunity to make them feel better and I hope I’ve provided you with the information you were looking for on how to treat your dog’s chemotherapy side effects!

360 MAGAZINE, Nicole Avena, PhD

Top Five Tips For Avoiding Colds and Flu This Season

1. Take It Easy. Stress is a sure way to compromise your immune system. Be sure to make sure that you are taking care of yourself and making time to rest and restore in order to keep your stress levels at a minimum.

2. Take Vitamin C. Supplementing your diet with Vitamin C is a great way to ward of colds and flu. We don’t typically get enough Vitamin C from our diets alone, so a supplement is often the best way to go. Vitafusion makes a Vitamin C gummy that is easy to take, and a great way to get your daily dose of Vitamin C.

3. Avoid Closed Places. Cold and flu viruses spread via the air, so try to avoid spending too much time indoors where there may be people who are sick (like shopping malls). Try to get outdoors as much as you can, as the brisk air can be great for your health and also very refreshing.

4. Wash Your Hands, and Face. Washing your hands is a no-brainer, but don’t forget to wash your face! We often touch our face with our hands, and germs can be sitting there just waiting to invade. 

5. Use Sanitizer. Keeping your work and home areas clean of viruses is important. Use sanitizer to wipe down the places where germs might be lingering, such as door knobs, bathrooms, faucet handles, and keyboards.

Nicole Avena, PhD, is Assistant Professor of Neuroscience at Mount Sinai School of Medicine. She is the author of several books, including Why Diets Fail, and What to Eat When You’re Pregnant. 

The Remarkable Life of David Hysong

Meet David Hysong — 30 year old adenoid cystic carcinoma patient and CEO of SHEPHERD Therapeutics. Here’s his remarkable story is below for consideration to pass along or speak with him about his journey:

Hysong finished his master’s degree in intellectual history in 2011 and found himself with a year’s lag time before he planned to enter the U.S. Navy. He was young, good looking, and smart. Most people in his position would probably have kicked back, gotten a job to pay the bills, and had some fun. However, David Hysong is not “most people.”

His story continues, and on a dare, he applied to Harvard Divinity School in 2012 for enrollment in the Fall. A series of educational and life adventures soon followed — good and bad, including his cancer diagnosis — and after graduation in May 2015, Hysong considered medical school. He took preparatory courses while working 80-hour weeks at two jobs to pay off medical and student debts. The schedule, in the wake of cancer treatment and graduate school, began to burn him out. Hysong then took a break for a few weeks. The clouds cleared and he was inspired to undertake what he calls “an impossible task”: a biotech start up that searched for cures to rare cancers like his.

Now, welcome SHEPHERD Therapeutics. His Genzyme and Harvard connections enabled him to assemble a world-class team of scientists. The firm’s goal is to find cures for the more than 250 rare cancers that make up 42 percent of cancer diagnoses in the United States. Hysong says that Shepherd is well on its way.

“We’ve raised close to $6.5M and we’re only just now finalizing our product portfolio,” he says. “The cool thing is, a lot of the times, therapeutics are approved when they represent a 30 percent survival rate or 40 percent survival rate. For the diseases we’re looking at, our preliminary data show about an 80 percent survival rate. We really think we’re going to be very successful and save a lot of lives.”

You can read David’s full story on Harvard Divinity School’s website, here: http://hds.harvard.edu/news/2017/12/07/Hysong-idealism-in-action#

Hysong was on the 2016 Forbes 30 Under 30 Healthcare list, and he was named as part of a class of 2017’s Future Biotech Giants. Not to mention he’s been covered by Southern Living, and he has spoken at the Forbes Under 30 Summit. SHEPHERD Therapeutics has offices in Boston and Nashville.