Posts tagged with "ICU"

Kaelen Felix Illustrates a Dental Article for 360 MAGAZINE

Oral Hygiene × SARS-CoV-2

The British Dental Journal recently found that poor oral hygiene may be linked to more severe cases of COVID-19 because of the harmful bacteria found in mouths that have not been properly taken care of.

While the mouth has always been known as a gateway to the rest of the body, giving it the ability to cause problems in other areas, it is now found that poor oral hygiene can cause respiratory infections, making COVID-19 stronger.

The good news is that the best defense, in this scenario, is to follow good oral practices, like flossing, brushing and using mouthwash.

COVID-19 continues to be deadly, but there does appear to be some sort of link in more than half of fatal cases.

According to the British Dental Journal, “More than 80% of COVID-19 patients in ICUs exhibited an exceptionally high bacterial load, with more than 50% of deaths exhibiting bacterial superinfections.”

Even though COVID-19 is transferred virally, complications like pneumonia and acute respiratory distress might be caused by bacterial superinfection, which begins in the mouth.

The study says, “We recommend that oral hygiene be maintained, if not improved, during a SARS-CoV-2 infection in order to reduce the bacterial load in the mouth and the potential risk of a bacterial superinfection.”

Again, hygiene can be maintained by brushing, flossing and using mouthwash, but oral-care probiotics can also offer protection.

Oral-care probiotics are a specialized type of probiotic formulated to repopulate the oral cavity bacteria, which battles harmful bacteria that could lead to cavities, gingivitis and periodontal disease.

Dr. Eric Goulder, founder of the Heart and Stroke Prevention Center of Central Ohio, said he thinks heart health is also determined by oral health. His team uses ProBiora, which supports health in teeth and gums.

“We think everyone should be extra careful during the pandemic, and oral-care probiotics are a great way to help keep the oral cavity in balance 24-7,” Dr. Goulder said.

To see the study, you can click right here.

DARPA selects Continuity Pharma to fund manufacturing technology

The COVID-19 pandemic has created supply chain gaps in critical drug products, especially those needed for the most critical patients in intensive care units across the country.

DARPA (Defense Advanced Research Project Agency) has selected Continuity Pharma, a Purdue University-affiliated company, to develop continuous manufacturing technology. The company was selected for a $1.5 million grant.

DARPA has established a competitive review process, awarding grant funding to companies presenting advanced manufacturing technologies.

Continuity Pharma’s mission is to apply novel continuous manufacturing capabilities to reshore generic drug products to the U.S., with specific focus on drugs in short supply.

“We are thrilled to be selected by DARPA to further our development efforts,” said David Thompson, a Purdue professor of organic chemistry and co-founder and chief scientific officer at Continuity. “We are one step closer to ensuring the availability of essential medicines to patients in need. It is an exciting time for Continuity Pharma.”

Grant specifics include development funding over the next 24 months, with additional funding for commercialization in the subsequent 12 months. Focus areas include capabilities for multiple API manufacturing in the Integrated Continuous Manufacturing System, with demonstrated efficiencies for rapid changeover and manufacturing efficiencies.

Continuity Pharma leaders are working with Purdue Research Foundationofficials to secure additional lab space in Purdue Research Park in West Lafayette.

About Continuity Pharma

Continuity Pharma was formed with the mission to ensure a consistent supply of high-quality essential medicines for patients in need. The company accomplishes this by applying analytical and process design expertise to create modular and portable continuous manufacturing systems for synthesizing essential generic medicines. Using high throughput methodologies, they identify the ideal reaction conditions for preparing the active pharmaceutical ingredients (API) to be manufactured efficiently in continuous flow. The result is a high yield of medical-grade API with the least toxic waste and the best opportunity for production on scale. For additional information or questions, contact the company at contact@continuitypharma.com or call 812-805-0038.

About Purdue Research Foundation

The Purdue Research Foundation is a private, nonprofit foundation created to advance the mission of Purdue University. Established in 1930, the foundation accepts gifts; administers trusts; funds scholarships and grants; acquires property; protects Purdue’s intellectual property; and promotes entrepreneurial activities on behalf of Purdue. The foundation manages the Purdue Foundry, Purdue Office of Technology Commercialization, Purdue Research Park, Purdue Technology Centers and University Development Office. In 2020, the IPWatchdog Institute ranked Purdue third nationally in startup creation and in the top 20 for patents. The foundation received the 2019 Innovation and Economic Prosperity Universities Award for Place from the Association of Public and Land-grant Universities. For more information on licensing a Purdue innovation, contact the Purdue Office of Technology Commercialization at otcip@prf.org. For more information about involvement and investment opportunities in startups based on a Purdue innovation, contact the Purdue Foundry at foundry@prf.org.

About Purdue University

Purdue University is a top public research institution developing practical solutions to today’s toughest challenges. Ranked the No. 5 Most Innovative University in the United States by U.S. News & World Report, Purdue delivers world-changing research and out-of-this-world discovery. Committed to hands-on and online, real-world learning, Purdue offers a transformative education to all. Committed to affordability and accessibility, Purdue has frozen tuition and most fees at 2012-13 levels, enabling more students than ever to graduate debt-free. See how Purdue never stops in the persistent pursuit of the next giant leap at purdue.edu.

Doctor illustration

Nurse Hospitalized Despite Negative COVID Test

By Eamonn Burke

Heather Valentine, a 24 year old ICU nurse in Houston, is now in the ICU with a case of the novel coronavirus. After noticing heightened exhaustion during her shifts and later a fever and cough, she got an antibody test. She came back negative, but according to the CDC these tests can be wrong around 50% of the time. A viral test for COVID, taken the next day, also came back negative. Her doctor, however, asked her to come in for a CT scan, and based on these results he was certain that she had the illness.

Initially skeptical that she had the virus, Valentine now spreads an important message. “You never think it’s going to happen to you, but I’m a perfect example,” she said. “Take every precaution, wear a mask, don’t go out if you don’t have to, it’s not worth it.”

This comes as Texas sees one of the worst bouts of COVID-19 in the world, seeing new records in cases daily. The hospitals are overrun and running out of supplies, as are many others across the country with the recent surge of the coronavirus across the nation.