Posts tagged with "topicals"

Cannabis, 360 MAGAZINE

High Times x RWB

High Times partners with Red, White & Bloom to rebrand and develop dispensaries in Michigan, Illinois, and Florida

Hightimes Holding Corp., the owner of High Times®, the most well-known brand in cannabis, today announces that it has entered into a series of agreements with Red, White & Bloom, Inc., also known as RWB, with the goal of the branding of High Times dispensaries and development of cannabis based CBD and THC products in the States of Michigan, Illinois and Florida.

RWB and its investee will use the Hightimes™ trademark, logo and brand to rebrand its 18 planned and operational dispensaries as High Times stores. Together, such stores represent more than 20% of the cannabis market share across the state. RWB’S Investee is the leading cannabis company in Michigan, with dispensaries, indoor/outdoor cultivation and product manufacturing established over the last two years. In addition, as a result of the acquisition of Newco, RWB will also acquire the rights to brand retail and medical dispensaries and products in the states of Illinois and Florida, and may utilize RWB’s 3.6 million square foot facility in Illinois for the production of CBD products and whole hemp flower strains for distribution nationally.

In addition to transforming the dispensaries to become High Times branded destinations and launching delivery capabilities in select locations, High Times branded vapes, tinctures, topicals, and edibles will be available within both owned dispensaries and other third party outlets. The company has aggressive growth plans and is entering the market at a time when the retail landscape has been significantly changed.

“High Times is a 46-year-old brand with an immense amount of recognition and credibility across the world,” said Peter Horvath, Chief Executive Officer of Hightimes Holding Corp. “Licensing the High Times name, advising on dispensary operations, and providing input on product development allows the company to drive significant revenue from licensing fees without assuming the complexity associated with owning and operating dispensaries and scaled cultivation and manufacturing facilities nationwide. RWB has built an incredible and expansive retail footprint in a quick time frame that we can strengthen through applying the High Times Brand.”

The Hightimes subsidiary holding the Hightimes™ trademark, logo and brand worldwide sublicensed such intellectual property to a new subsidiary, Newco, for the purpose of using and branding retail and medical dispensaries and products in Michigan, Illinois, and Florida. Under the terms of the agreement, the Hightimes Licensing Company sold RWB 100% of the equity of Newco. In return, the Hightimes Licensing Company will receive $15 million of RWB common shares which are expected to trade on the Canadian Securities Exchange and may receive an additional $5 million of RWB common shares in the future. In addition, the Hightimes Licensing Company expects certain Minimum Guarantee payments during the term of the agreement and any renewal period.

Hightimes Holding Corp. has also recently announced the appointment of CEO Peter Horvath and its planned acquisition of 13 California dispensaries from Harvest Health & Recreation, one of the largest multi-state operators in cannabis. Through these initiatives, High Times intends to become one of the largest cannabis companies in California, and is working quickly to do the same in Michigan, Illinois and Florida.

About High Times

For more than 45 years, High Times has been the world’s most well-known
cannabis brand – championing the lifestyle and educating the masses on
the benefits of this natural flower. From humble beginnings as a
counterculture lifestyle publication, High Times has evolved into
hosting industry-leading events like the Cannabis Cup and the High
Times Business Summit, while providing digital TV and social networks,
globally distributed merchandise, international licensing deals and
providing content for its millions of fans and supporters across the
globe. In the world of Cannabis, High Times is the arbiter of quality.
For more information on High Times visit their website here.

About Red White & Bloom

Red White & Bloom, building on its first mover advantage (through its
investments and pending acquisitions in the states of Michigan,
Florida, Massachusetts and Illinois) is a multi-state operator that
enters markets at scale. The Company’s portfolio (following completion
of the pending acquisitions) will include superior brands and
proprietary product development capabilities, focused on a “house of
brands” strategy in both cannabis as well as hemp-derived products.

CBD, Vaughn Lowery, 360 MAGAZINE

CBD – Finding the Right Option and Optimal Dosage for You

So, you have decided to start using CBD to relieve your health issues. But now, you’re facing a tough decision: what are the best CBD oils? Should you consider edibles, tinctures, vaporizers, or topicals instead? And what is the ideal dosage?

If the great number of different CBD products seems overwhelming, you’re not alone. Different products affect the body differently. In addition, every individual responds differently to CBD depending on a number of factors like age, weight and the condition being treated. All this affects what form of CBD you should use and how much you should take.

This article aims to help you work out a CBD treatment plan tailored to your individual needs and health goals.

What is Your Goal?

Start by determining your health goal. What do you want CBD to help you with? Are you struggling with anxiety? Do you need help with chronic pain?

You also need to determine what area in your body you are targeting, because, in order to be effective, CBD needs to arrive where it is needed. If the target is somewhere on your skin (e.g. acne), then you should try using CBD topicals (lotion or cream). This will ensure that a high concentration of CBD is used just where you need it, instead of having to move through your bloodstream until it reaches the target.

Are You Looking for Immediate Effects?

If you are looking for quick relief, inhaled CBD products (vaporizers) are the best choice for you. If you want to keep the CBD levels constant throughout the day, opt for oral products (oil, edibles, capsules, tinctures).

What’s the Ideal Dosage?

The effectiveness of each CBD product depends on a number of individual factors so, the dosage is also a very individual process.

It’s always best to begin with small dosages and see how your body reacts. If there are no adverse side effects, then you can gradually increase the dosage.

Even if you find the ideal dosage, it might change if you start using a product from a different manufacturer.

Can You Overdose on CBD?

Clinical trials have found that humans can take up to 1,200 mg of CBD per day without experiencing any side effects.

However, it’s always recommended to consult with your doctor before you start using any CBD products, especially if you’re already taking any prescription medications.

What’s Type of CBD is the Best?

Research has found that full-spectrum CBD products are more effective than CBD isolates because they contain all or nearly all of the compounds present in the cannabis plant. These compounds interact with each other in the body, thus enhancing CBD’s therapeutic effects.

Final Thoughts

CBD is quite a complicated subject that researchers are still trying to piece together. There aren’t any fixed guidelines to follow when it comes to using CBD to achieve your health goals. It is a highly personal experience that requires patience and experimentation.

CBD: An Alternative to Prescription Drugs?

In the modern world, our first approach to treating an illness is to find the most suitable pharmaceutical drug, which we typically get either over-the-counter or on prescription. However, while these medicines are normally effective, they can unlock a whole new box of issues, including dependency and side effects.

Becoming reliant on medication can be mentally unsettling, and nasty side effects like nausea and dizziness typically require further treatment, leaving patients on a cocktail of pharmaceutical-grade drugs before they know it.

In the case of opioid painkillers, dependency may even be life-threatening, with the risk of overdose frighteningly high. In 2016, abuse of prescription opioid painkillers and recreational opiates accounted for more than 40,000 US lives, according to the Centers for Disease Control and Prevention (CDC).

This cycle of illness, drugs, side effects and more drugs is wearing thin with many, and combined with the new wave of medical cannabis science, a clear divide has formed between those who favor prescription drugs, and those who’d rather take natural, plant-based medicines.

From a historical perspective, medicinal cannabis use makes perfect sense, with the herb being used for millennia across the world, but particularly in Africa and Asia.

Technological advancements have greatly developed our knowledge of cannabis, and scientists now know which compounds are responsible for various effects. For example, the psychoactive “high” mostly comes from a therapeutic cannabinoid called tetrahydrocannabinol (THC). However, numerous other cannabinoids have medicinal properties, sans the hallucinogenic effects.

Cannabidiol (CBD) is the most studied and seemingly most useful non-intoxicating cannabinoid, and the market for CBD products has exploded in the 2010s, thanks in part to the relaxation of laws surrounding non-psychoactive hemp.

CBD over opioids
Opioid-based painkillers like Tramadol are now regularly prescribed for chronic pain, with stronger synthetic drugs such as fentanyl available on prescription for the most extreme discomfort. These drugs are designed to interact with opioid receptors in the opioid system. The pain relief from these drugs is substantial, however sustained use leads to increased tolerance, stronger doses and addiction.

However, CBD may be helpful for chronic patients, and also those who have ended up dependent on opioids, as the cannabinoid seems to exhibit anti-addiction properties by interfering with pleasure-reward mechanisms.

By elevating concentrations of anandamide in the body, CBD is promoting a neurotransmitter that works to ease both physical and mental pain. How CBD tackles addiction is less clear, but some evidence indicates that CBD is active in the opioid system.

Not all pain is the same – for example, some chronic pain is persistent and always at a similar intensity, whereas the worst effects of inflammatory and neuropathic pain tend to come from flare-ups.

For internal neuropathic pain, CBD vape oil and e-liquid treatment is ideal, because the relief comes very quickly. Meanwhile, lingering pain is economically and perhaps more efficiently managed by orally-consumed CBD products (e.g. capsules, edibles, coffee).

Experimenting with gels, creams and balms infused with cannabis or CBD is a novel method of coping with localized pain. These ensure that the cannabinoid receptors in the affected area are directly activated.

If you’re unsure where to start searching for the right CBD product and form for your pain or you simply can’t decide with the long list of options, you can click here to learn more.

CBD: the new anti-inflammatory drug?
Immune system response is still not well that understood, and this has made it difficult to control. Researchers have struggled to find ways of influencing inflammation, but studies into the endocannabinoid system have found that immune system response is accessible via cannabinoid receptor 2 (CB2). Endocannabinoids look to signal a stoppage in inflammation, after a wound has fully healed or an infection is neutralized.

This discovery may be crucial, as the current leading class of anti-inflammatories (non-steroidal anti-inflammatory drugs, or NSAIDs) are known to cause concerning side effects, including stomach ulcers.

The best CBD product for inflammation depends, unsurprisingly on the type of inflammation. Internal conditions like irritable bowel syndrome (IBS), which could be exacerbated by endocannabinoid deficiency, respond well to both CBD vape juice and CBD edibles, or even tincture oils.

For osteoarthritis, a form of inflammation which affects the joints, CBD creams and other topicals are likely to produce better results.

CBD’s promise as an antidepressant
Cannabinoid research is providing genuine hope for antidepressant researchers, after decades of stagnation in medication development. The current situation with depression medicine is far from ideal, with selective serotonin reuptake inhibitors (SSRIs) slow to show benefits – for up to 40 percent of patients, these drugs may not even work at all. And then there are the side effects to contend with, which range from drowsiness to impotence. Depersonalization and derealization have also been anecdotally reported with SSRIs.

However, a glut of promising studies on CBD and the brain have found that the ECS could be important in correcting off-balance brain chemistry. The CB1 receptor modulates many variables, mood being one, and the bond between anandamide and this receptor is important for good mental wellbeing. Factors outside of the ECS also affect mood, but the potency of anandamide as an antidepressant makes the link with the CB1 receptor an essential one.

Some of the most exciting research on cannabinoids has been on their neuroprotective and neurogenesis properties. Studies on the hippocampus and the prefrontal cortex and cannabinoid treatments, which are associated with depression, have demonstrated that CBD is able to repair these regions of the brain, by restoring neuronal circuitry and helping to form new brain cells.

A 2018 study on rats carried out in Brazil showed that CBD was effective from the first treatment and for up to seven days after the last dose at blocking synaptic proteins which damage neuronal circuitry in the prefrontal cortex. Meanwhile, CBD-initiated neurogenesis in the hippocampus helps to regrow the brains of adult rats with depression. These results have not yet been replicated in humans, but rats are used for such studies because their brains are similar to humans. General memories and our autobiographical memory are stored in the hippocampus.

The only CBD products that aren’t suitable for managing depression are topicals, as the cannabinoids remain in the skin, and do not reach the brain.